| Yazarlar (6) |
Prof. Dr. Fatma KANDEMİRLİ
Kastamonu Üniversitesi, Türkiye |
Saima Rasheed
|
|
Hakan Sezgin Sayiner
Adıyaman Üniversitesi, Türkiye |
|
Yusuf Akkaya
|
Doç. Dr. Can Doğan VURDU
Kastamonu Üniversitesi, Türkiye |
|
Iqbal Choudhary
|
| Özet |
| Isatin thiosemicarbazone and its metal complexes have been prepared and structurally characterized by elemental analyses and FT-IR, electronic and 1H-NMR, 13C-NMR spectra. The theoretical wavenumbers, IR intensities, 1H-NMR, 13C-NMR spectroscopy, UV absorption spectra and and molecular parameters were calculated by the B3LYP method. Frontier molecular orbital energies, bond length and charges on the atoms of I4NPTH2 and I2-4CPTH2 were studied by the B3LYP method using 6-31G (d, p), 6-311G (d, p), 6-311++ G (d, p), 6-311++ G (2d, 2p) basis sets in gas and DMSO phases. Results showed that compounds 8, 10 and 5 are potent inhibitors of in vitro protein glycation with IC50 value of 111.30±1.96, 113.00±0.9 and 161.51±0.47 µM, respectively While compounds 1-4 were found to be inactive. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | Uluslararası alan indekslerindeki dergilerde yayınlanan tam makale |
| Dergi Adı | Journal of Chemical and Pharmaceutical Research |
| Dergi ISSN | 0975-7384 Scopus Dergi |
| Dergi Tarandığı Indeksler | PUBMED, NCBI Database, EBSCO Host databases, USA |
| Makale Dili | İngilizce |
| Basım Tarihi | 04-2015 |
| Cilt No | 7 |
| Sayı | 3 |
| Sayfalar | 44 / 55 |
