Investigation of VKORC1 Gene Polymorphism in Patients with Bleeding Complaints due to Warfarin
Yazarlar (6)
Prof. Dr. Fatma Mutlu KUKUL GÜVEN Kastamonu Üniversitesi, Türkiye
Prof. Dr. Celal Yavuz Dicle Üniversitesi, Türkiye
Kenan Ahmet Türkdoğan
Sağlık Bilimleri Üniversitesi, Türkiye
Sağlık Bilimleri Üniversitesi, Türkiye
Prof. Dr. Oğuz Karahan Alanya Alaaddin Keykubat Üniversitesi, Türkiye
Ahmet Çalışkan
Prof. Dr. Memet Yusuf Çelik Biruni Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (Diğer hakemli uluslarası dergilerde yayınlanan tam makale) | ||
| Dergi Adı | International Journal of Basic and Clinical Studies (IJBCS) | ||
| Dergi ISSN | 2147-1428 | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2012 |
| Cilt / Sayı / Sayfa | 1 / 2 / 27–40 | DOI | – |
| Makale Linki | http://www.ijbcs.com/images/stories/doc/Investigaition20of20VKORC120Gene20Polymorphism20in.pdf | ||
| UAK Araştırma Alanları |
Acil Tıp
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| Özet |
| Objective: In the current study, the effect of genetic mutation was investigated on the patients referred to the emergency department due to the complaints of bleeding which receiving oral anticoagulant.Method: The blood samples of 80 patients referred to emergency department with the complaints of bleeding who was using oral anticoagulants with any reason and of 40 healthy individuals were stored. The DNA was obtained from each sample with PCR amplification method and VKORC1 gene polymorphisms were scanned in DNA samples.Results: The patient and the control group were consisted of similar age and gender. On the scanning of VCOR gene, homozygote mutation was detected in 4 (5%) patients, while heterozygote mutation was defined in 51 (64%) of the cases and normal genotype were in 25 |
| Anahtar Kelimeler |
