| Yazarlar (6) |
Prof. Dr. Fatma Mutlu KUKUL GÜVEN
Kastamonu Üniversitesi, Türkiye |
Celal Yavuz
Dicle Üniversitesi, Türkiye |
|
Kenan Ahmet Türkdoğan
Sağlık Bilimleri Üniversitesi, Türkiye |
|
Oğuz Karahan
Alanya Alaaddin Keykubat Üniversitesi, Türkiye |
|
Ahmet Çalışkan
|
|
Memet Yusuf Çelik
Biruni Üniversitesi, Türkiye |
| Özet |
| Objective: In the current study, the effect of genetic mutation was investigated on the patients referred to the emergency department due to the complaints of bleeding which receiving oral anticoagulant.Method; The blood samples of 80 patients referred to emergency department with the complaints of bleeding who was using oral anticoagulants with any reason and of 40 healthy individuals were stored. The DNA was obtained from each sample with PCR amplification method and VKORC1 gene polymorphisms were scanned in DNA samples. Kontrol grubunda Results: The patient and the control group were consisted of similar age and gender. On the scanning of VCOR gene, homozygote mutation was detected in 4 (5%) patients, while heterozygote mutation was defined in 51 (64%) of the cases and normal genotype were in 25 (31%) cases in patient group. Heterozygote mutation was found at 28 (70%) individual … |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | Diğer hakemli uluslarası dergilerde yayınlanan tam makale |
| Dergi Adı | International Journal of Basic and Clinical Studies (IJBCS) |
| Dergi ISSN | 2147-1428 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2012 |
| Cilt No | 1 |
| Sayı | 2 |
| Sayfalar | 27 / 40 |
| Makale Linki | http://www.ijbcs.com/images/stories/doc/Investigaition20of20VKORC120Gene20Polymorphism20in.pdf |
