| Yazarlar (4) |
Prof. Dr. Fatma Mutlu KUKUL GÜVEN
Cumhuriyet Üniversitesi, Türkiye |
Abdulkerim Yılmaz
Cumhuriyet Üniversitesi, Türkiye |
|
Hüseyin Aydın
Cumhuriyet Üniversitesi, Türkiye |
|
İlhan Korkmaz
Cumhuriyet Üniversitesi, Türkiye |
| Özet |
| Diabetes mellitus (DM) is associated with platelet dysfunction. In diabetic patients, alterations in platelet functions, especially increased platelet agregation, have been suggested to cause increasing in cardiovascular morbidity and mortality or in accelaretion of athersclerotic process. In this study, we aimed to investigate the platelet aggregation response alterations and the effects of DM duration, HbA1c, treatment options among the patients with Type 2 DM. Fortyfive patients (case group; 21 male, 24 female) with Type 2 DM and forty-eight healthy individuals (control group; 22 male, 26 female) were included in this study. Platelet aggregation was determinated with Chorono-log 500 (USA) named device by using Chorono-log/ADP, Chorono-log/collagen and Chorono-log/epinephrine kits. ADP-induced platelet aggregation was significantly higher in the case group compared with control group (p< 0.05). Epinephrine induced platelet aggregation were significant in negatively correlation with the diabetes duration (P< 0.05). Platelet aggregation responses did not differ according to their treatment type (sulphonylurea or insulin) was statistically insignificiant among the case groups (p> 0.05). In conclusion, our findings supported that type 2 diabetes may interfere with platelet functions without any relationship age, gender, the treatment types and the regulation levels. These findings supports that existence potential new factors or mechanism affecting platelet agregation. The subject requires more detailed studies in the future. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | Diğer hakemli uluslarası dergilerde yayınlanan tam makale |
| Dergi Adı | Health |
| Dergi ISSN | 1949-5005 |
| Dergi Tarandığı Indeksler | CABI databases |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2010 |
| Cilt No | 2 |
| Sayı | 7 |
| Sayfalar | 708 / 712 |
| Doi Numarası | doi:10.4236/health.2010.27108 |
| Atıf Sayıları | |
| Google Scholar | 20 |
