| Yazarlar |
Nihat Yumuşak
Türkiye |
|
Akın Yiğin
Türkiye |
|
Pelin Fatoş Polat Dinçer
Türkiye |
Doç. Dr. Mustafa HİTİT
Kastamonu Üniversitesi, Türkiye |
|
Rahşan Yılmaz
Türkiye |
| Özet |
| The aim of the present study was to investigate the role of ADAMTS-7 gene in the pathogenesis of myocardial dystrophy associated with white muscle disease (WMD) in lambs. A total of 217 cardiac tissue samples from lambs with WMD were used in the study. Histopathological sections of the samples were stained with hematoxylin-eosin (HE) and examined using Western-blot, real-time PCR (RT-PCR) and immunohistochemistry for ADAMTS-7 gene expression, and the findings were statistically evaluated. Histopathological examinations revealed fibrosis associated with hyalinization, necrosis and granular calcifications in cardiomyocytes. Western blot and RT-PCR showed a statistically significant upregulation of ADAMTS-7 (p?0.05) (p?0.05). Immunohistochemical analyses showed that immunopositive cell numbers significantly high for ADAMTS-7 (p?0.05). The study has revealed that ADAMTS-7 gene is significantly expressed in myocardial dystrophy associated with WMD in addition to its role in the pathogenesis of this disease. |
| Anahtar Kelimeler |
| ADAMTS-7 | Lamb | Myocardial dystrophy | White muscle disease |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Polish Journal of Veterinary Sciences |
| Dergi ISSN | 1505-1773 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q3 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2018 |
| Cilt No | 21 |
| Sayı | 1 |
| Sayfalar | 119 / 126 |
| Doi Numarası | 10.24425/119029 |
| Makale Linki | https://journals.pan.pl/pjvs/119601#tabs |
| Atıf Sayıları | |
| SCOPUS | 4 |
