Expression of ADAMTS-7 in myocardial dystrophy associated with white muscle disease in lambs
Yazarlar (5)
Nihat Yumuşak Türkiye
Doç. Dr. Akın Yiğin Türkiye
Mustafa Hitit Kastamonu Üniversitesi, Türkiye
Prof. Dr. Rahşan Yılmaz Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Polish Journal of Veterinary Sciences (Q3) | ||
| Dergi ISSN | 1505-1773 Dergi Bilgileri (2018) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2018 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 13-02-2018 |
| Cilt / Sayı / Sayfa | 21 / 1 / 119–126 | DOI | 10.24425/119029 |
| Makale Linki | http://journals.pan.pl/Content/103573/PDF/14.pdf | ||
| UAK Araştırma Alanları |
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| Özet |
| The aim of the present study was to investigate the role of ADAMTS-7 gene in the pathogenesis of myocardial dystrophy associated with white muscle disease (WMD) in lambs. A total of 217 cardiac tissue samples from lambs with WMD were used in the study. Histopathological sections of the samples were stained with hematoxylin-eosin (HE) and examined using Western-blot, real-time PCR (RT-PCR) and immunohistochemistry for ADAMTS-7 gene expression, and the findings were statistically evaluated. Histopathological examinations revealed fibrosis associated with hyalinization, necrosis and granular calcifications in cardiomyocytes. Western blot and RT-PCR showed a statistically significant upregulation of ADAMTS-7 (p?0.05) (p?0.05). Immunohistochemical analyses showed that immunopositive cell numbers significantly high for ADAMTS-7 (p?0.05). The study has revealed that ADAMTS-7 gene is significantly expressed in myocardial dystrophy associated with WMD in addition to its role in the pathogenesis of this disease. |
| Anahtar Kelimeler |
| ADAMTS-7 | Lamb | Myocardial dystrophy | White muscle disease |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |