The role of heparan sulphate in pathogenesis of Crimean Congo hemorrhagic fever disease
Yazarlar (8)
Prof. Dr. Fatma Mutlu KUKUL GÜVEN Cumhuriyet Üniversitesi, Türkiye
Prof. Dr. Hüseyin Aydın Cumhuriyet Üniversitesi, Türkiye
Ali Kaya
Aynur Engin Cumhuriyet Üniversitesi, Türkiye
Prof. Dr. Veysel Kenan Çelik Cumhuriyet Üniversitesi, Türkiye
Prof. Dr. İlhan Korkmaz Cumhuriyet Üniversitesi, Türkiye
Atlı Bahri
Dilara Füsun İçağasıoğlu Cumhuriyet Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | JOURNAL OF VECTOR BORNE DISEASES | ||
| Dergi ISSN | 0972-9062 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2013 |
| Cilt / Sayı / Sayfa | 50 / 2 / 133–136 | DOI | – |
| UAK Araştırma Alanları |
Acil Tıp
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| Özet |
| Methods:In this study, the patient group consisted of 79 cases with a positive diagnosis of CCHF according to PCR/ELISA outcome among the patients referred to Cumhuriyet University, School of Medicine in 2010. A total of 81 volunteers who had not any viral or metabolic disease were enrolled as the control group. The blood samples were centrifuged, and the serum and urine samples obtained were stored at–80 C until they were studied. Then, these samples were simultaneously dissolved, and HS level was spectrophotometrically measured using glycosaminoglycans specific 1–9, dimethyl-methylene blue (DMMB) stain.Results:A statistically significant increase in the HSserum values was found both in the individuals under and above 16 yr old in the patient groups compared to the controls (p< 0.05). Also there was a statistically significant increase in the urine levels of HS in the cases> 16 yr old compared to the … |
| Anahtar Kelimeler |
| Crimean-Congo hemorrhagic fever | hemorrhage | heparan sulphate | viral infections |
