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The role of heparan sulphate in pathogenesis of Crimean Congo hemorrhagic fever disease      
Yazarlar
Prof. Dr. Fatma Mutlu KUKUL GÜVEN Prof. Dr. Fatma Mutlu KUKUL GÜVEN
Cumhuriyet Üniversitesi, Türkiye
Hüseyin Aydın
Cumhuriyet Üniversitesi, Türkiye
Ali Kaya
Aynur Engin
Cumhuriyet Üniversitesi, Türkiye
Veysel Kenan Çelik
Cumhuriyet Üniversitesi, Türkiye
İlhan Korkmaz
Cumhuriyet Üniversitesi, Türkiye
Atlı Bahri
Dilara Füsun İçağasıoğlu
Cumhuriyet Üniversitesi, Türkiye
Özet
Crimean-Congo hemorrhagic fever (CCHF) is a viral infection typically transmitted by tick bite. This study is to define the level of heparan sulphate (HS) in serum/urine since HS may play a role in the pathogenesis of hemorrhagic events in the patients with CCHF. In this study, the patient group consisted of 79 cases with a positive diagnosis of CCHF according to PCR/ELISA outcome among the patients referred to Cumhuriyet University, School of Medicine in 2010. A total of 81 volunteers who had not any viral or metabolic disease were enrolled as the control group. The blood samples were centrifuged, and the serum and urine samples obtained were stored at - 80°C until they were studied. Then, these samples were simultaneously dissolved, and HS level was spectrophotometrically measured using glycosaminoglycans specific 1- 9, dimethyl-methylene blue (DMMB) stain. A statistically significant increase in the HSserum values was found both in the individuals under and above 16 yr old in the patient groups compared to the controls (p <0.05). Also there was a statistically significant increase in the urine levels of HS in the cases >16 yr old compared to the controls (p <0.05). Increase of the serum/urine levels of HS was though to be due to vascular endothelium damage and to liver injury as well as vascular endothelium damage in the patients who died. Further, comprehensive studies are needed to demonstrate whether the serum/urine levels of HS are correlated to liver and vascular endothelium damage and prognosis of the disease.
Anahtar Kelimeler
Crimean-Congo hemorrhagic fever | hemorrhage | heparan sulphate | viral infections
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı JOURNAL OF VECTOR BORNE DISEASES
Dergi ISSN 0972-9062
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili İngilizce
Basım Tarihi 06-2013
Cilt No 50
Sayı 2
Sayfalar 133 / 136
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
WoS 5
Google Scholar 6

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