| Yazarlar |
Halef Okan Doğan
Cumhuriyet Üniversitesi, Türkiye |
|
Hüseyin Aydın
Cumhuriyet Üniversitesi, Türkiye |
|
Özlem Demirpençe
Cumhuriyet Üniversitesi, Türkiye |
Prof. Dr. Fatma Mutlu KUKUL GÜVEN
Cumhuriyet Üniversitesi, Türkiye |
|
Yusuf Kenan Tekin
Cumhuriyet Üniversitesi, Türkiye |
|
Ali Şahin
Cumhuriyet Üniversitesi, Türkiye |
| Özet |
| Aim: The aim of this study was to determine the relationship between oxidative status,matrix metalloproteinase-9 (MMP-9),matrix metalloproteinase-2 (MMP-2) and tissue metallopeptidase inhibitor-1 (TIMP-1) in patients with acute exacerbation chronic obstructive pulmonary disease (AECOPD). Material and Method: The study included a total of 35 patients with acute exacerbated COPD and 35 healthy nonsmoker controls. We assessed the concentrations of MMP-2,MMP-9,TIMP-1,total antioxidant status (TAS),and total oxidant status (TOS) in the study population. Results: MMP-9 concentrations were found as 201.19±12.91 pg/mL and 189.32±13.01 pg/mL in patients and controls,respectively. TAS concentrations were found as 20.27± 2.99 μmol trolox equiv/l and 17.69±2.96 μmol trolox equiv/l in patients and controls,respectively. Significant differences were found between patients and controls in terms of MM9 and TAS (< .001) concentrations. We also found lower TIMP-1 concentrations in patients (p=.035) than controls. We also found correlation between MMP-9,TAS (r=0.484,p<.001) and the oxidative status index (r= 0.221,p<.001). However,we did not find any significant correlation between MMP-2,TIMP-1,and oxidative stress markers (TAS and TOS). Discussion: It is thought that the antioxidant treatment approaches could be beneficial for AECOPD patients for preventing the MMP-9 related inflammation. |
| Anahtar Kelimeler |
| AECOPD | MMP-2 | MMP-9 | Oxidative stress | TIMP-1 |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | ESCI dergilerinde yayımlanan tam makale |
| Dergi Adı | JOURNAL OF CLINICAL AND ANALYTICAL MEDICINE |
| Dergi ISSN | 1309-0720 |
| Dergi Tarandığı Indeksler | ESCI: Emerging Sources Citation Index |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2017 |
| Cilt No | 8 |
| Sayı | 1 |
| Sayfalar | 64 / 67 |
| Doi Numarası | 10.4328/JCAM.4718 |
| Atıf Sayıları | |
| WoS | 1 |
| SCOPUS | 3 |
| Google Scholar | 2 |
