Matrix Metalloproteinases and Oxidative Stress in Patients with AECOPD
Yazarlar (6)
Halef Okan Doğan Cumhuriyet Üniversitesi, Türkiye
Prof. Dr. Hüseyin Aydın Cumhuriyet Üniversitesi, Türkiye
Özlem Demirpençe
Cumhuriyet Üniversitesi, Türkiye
Cumhuriyet Üniversitesi, Türkiye
Prof. Dr. Fatma Mutlu KUKUL GÜVEN Cumhuriyet Üniversitesi, Türkiye
Prof. Dr. Yusuf Kenan Tekin Cumhuriyet Üniversitesi, Türkiye
Prof. Dr. Ali Şahin Cumhuriyet Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(ESCI dergilerinde yayınlanan tam makale)
|
||
| Dergi Adı | Journal of Clinical and Analytical Medicine | ||
| Dergi ISSN | 1309-0720 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | ESCI: Emerging Sources Citation Index | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2017 |
| Cilt / Sayı / Sayfa | 8 / 1 / 64–67 | DOI | 10.4328/JCAM.4718 |
| Makale Linki | http://www.bayrakol.org/en/2017/january2017/original-article/item/download/88_a4f23171745e64d2a93e71f9d445daad | ||
| UAK Araştırma Alanları |
Fen Bilimleri ve Matematik
|
||
| Özet |
| Aim The aim of this study was to determine the relationship between oxidative status, matrix metalloproteinase-9 (MMP-9), matrix metalloproteinase-2 (MMP-2) and tissue metallopeptidase inhibitor-1 (TIMP-1) in patients with acute exacerbation chronic obstructive pulmonary disease (AECOPD). Material and Method The study included a total of 35 patients with acute exacerbated COPD and 35 healthy nonsmoker controls. We assessed the concentrations of MMP-2, MMP-9, TIMP-1, total antioxidant status (TAS), and total oxidant status (TOS) in the study population. Results MMP-9 concentrations were found as 201.19 +/- 12.91 pg/mL and 189.32 +/- 13.01 pg/mL in patients and controls, respectively. TAS concentrations were found as 20.27 +/- 2.99 mu mol trolox equiv/l and 17.69 +/- 2.96 mu mol trolox equiv/l in patients and controls, respectively. Significant differences were found between patients and controls in terms of MM9 and TAS (<.001) concentrations. We also found lower TIMP-1 concentrations in patients (p=. 035) than controls. We also found correlation between MMP-9, TAS (r= 0.484, p<. 001) and the oxidative status index (r= 0.221, p<. 001). However, we did not find any significant correlation between MMP-2, TIMP-1, and oxidative stress markers (TAS and TOS). Discussion It is thought that the antioxidant treatment approaches could be beneficial for AECOPD patients for preventing the MMP-9 related inflammation. |
| Anahtar Kelimeler |
| AECOPD | MMP-2 | MMP-9 | Oxidative stress | TIMP-1 |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 3 |
| Scopus | 4 |
| Google Scholar | 4 |