Multi-targeted potential of Pittosporum senacia Putt.: HPLC-ESI-MSn analysis, in silico docking, DNA protection, antimicrobial, enzyme inhibition, anti-cancer and apoptotic activity
Yazarlar (9)
Mohamad Fawzi Mahomoodally
University Of Mauritius, Mauritius
University Of Mauritius, Mauritius
Carene Picot-Allain
University Of Mauritius, Mauritius
University Of Mauritius, Mauritius
M. Hosenally
University Of Mauritius, Mauritius
University Of Mauritius, Mauritius
Asli Ugurlu
Kastamonu Üniversitesi, Türkiye
Kastamonu Üniversitesi, Türkiye
Adriano Mollica University Of G. D'annunzio Chieti And Pescara, İtalya
Azzurra Stefanucci University Of G. D'annunzio Chieti And Pescara, İtalya
E. J. Llorent-Martínez Universidad De Jaén, İspanya
Prof. Dr. Mehmet Cengiz BALOĞLU Kastamonu Üniversitesi, Türkiye
Prof. Dr. Gokhan Zengin Selçuk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Computational Biology and Chemistry (Q1) | ||
| Dergi ISSN | 1476-9271 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2019 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-12-2019 |
| Cilt / Sayı / Sayfa | 83 / 1 / 107114–0 | DOI | 10.1016/j.compbiolchem.2019.107114 |
| Makale Linki | https://www.sciencedirect.com/science/article/abs/pii/S1476927119306590! | ||
| UAK Araştırma Alanları |
Biyoteknoloji
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| Özet |
| Pittosporum senacia (PS) Putt. (Pittosporaceae), indigenous to the Mascarene Islands, is a common ingredient in traditional medicines. However, there is currently a dearth of studies to validate some of these traditional claims. Given the broad traditional uses of PS against several diseases, we aimed to provide a comprehensive insight into the biological and chemical profile of P. senacia. The antioxidant, enzyme inhibitory activity, anticancer, and phytochemical composition of the methanolic extract of P. senacia leaf extracts were studied. The possible interaction and binding mode of the most abundant phytochemicals were studied via in silico docking experiments on tyrosinase and α-glucosidase. The mechanism behind the cytotoxic property of P. senacia extract for MDA-MB-231 was also examined using different methods including 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) cell viability … |
| Anahtar Kelimeler |
| Antimicrobial | Apoptosis | Diabetes | Mauritius | Pittosporaceae |
Science Direct
Multi-targeted potential of Pittosporum senacia Putt.: HPLC-ESI-MSn analysis, in silico docking, DNA protection, antimicrobial, enzyme inhibition, anti-cancer and apoptotic activity
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 22 |
| Google Scholar | 25 |