| Yazarlar |
Şevki Hakan Eren
Gaziantep Üniversitesi, Türkiye |
|
İlhan Korkmaz
Sivas Cumhuriyet Üniversitesi, Türkiye |
Prof. Dr. Fatma Mutlu KUKUL GÜVEN
Kastamonu Üniversitesi, Türkiye |
|
Yusuf Kenan Tekin
Sivas Cumhuriyet Üniversitesi, Türkiye |
|
Levent Özdemir
Bursa Uludağ Üniversitesi, Türkiye |
| Özet |
| OBJECTIVES: Consumption of toxic species of mushrooms may have detrimental effects and increase oxidative stress. Paraoxonase, arylesterase and glutathione-S-transferase are antioxidants that resist oxidative stress. In this study, we analyzed the changes in these enzymes during intoxication due to mushrooms. METHODS: The study enrolled 49 adult patients with a diagnosis of mushroom poisoning according to clinical findings and 49 healthy volunteers as the control group. The patients with mild clinical findings were hospitalized due to the possibility that the patient had also eaten the mushrooms and due to clinical findings in the late period, which could be fatal. Paraoxonase, arylesterase, and glutathione-S-transferase concentrations, as well as total antioxidant and oxidant status, were determined in the 49 patients and 49 healthy volunteers by taking blood samples in the emergency department. RESULTS: While paraoxonase, arylesterase, and total antioxidant status were significantly decreased in the patient group (p<0.05), glutathione-S-transferase, total oxidant status and the oxidative stress index were significantly higher (p<0.05). There was a positive correlation between the hospitalization time and the oxidative stress index (r=0.752, p<0.001), whereas a negative correlation was found with glutathione-S-transferase (r=-0.420, p=0.003). CONCLUSION: We observed a significant decrease in paraoxonase and arylesterase and an increase in glutathione-S-transferase and oxidative stress indexes in patients with mushroom poisoning, indicating that these patients had an oxidative status. In particular, a low total antioxidant status and high oxidative stress index may gain importance in terms of the assessment of hospitalization duration. |
| Anahtar Kelimeler |
| Oxidative Stress,Antioxidant Status,Mushroom Poisoning,Emergency Service,Hospitalization Time |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Clinics |
| Dergi ISSN | 1807-5932 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 06-2019 |
| Cilt No | 73 |
| Sayı | 16 |
| Sayfalar | 1 / 5 |
| Makale Linki | http://dx.doi.org/10.6061/clinics/2018/e16-550 |
