Serum Paraoxonase, Arylesterase, and Glutathione-S-Transferase Activities and Oxidative Stress Levels inPatients with Mushroom Poisoning
Yazarlar (5)
Prof. Dr. Şevki Hakan Eren Gaziantep Üniversitesi, Türkiye
Prof. Dr. İlhan Korkmaz Sivas Cumhuriyet Üniversitesi, Türkiye
Prof. Dr. Fatma Mutlu KUKUL GÜVEN Kastamonu Üniversitesi, Türkiye
Prof. Dr. Yusuf Kenan Tekin Sivas Cumhuriyet Üniversitesi, Türkiye
Levent Özdemir Bursa Uludağ Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Clinics (Q3) | ||
| Dergi ISSN | 1807-5932 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2019 |
| Cilt / Sayı / Sayfa | 73 / 1 / 1–5 | DOI | 10.6061/clinics/2018/e16-550 |
| Makale Linki | http://dx.doi.org/10.6061/clinics/2018/e16-550 | ||
| UAK Araştırma Alanları |
Fen Bilimleri ve Matematik
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| Özet |
| OBJECTIVES Consumption of toxic species of mushrooms may have detrimental effects and increase oxidative stress. Paraoxonase, arylesterase and glutathione-S-transferase are antioxidants that resist oxidative stress. In this study, we analyzed the changes in these enzymes during intoxication due to mushrooms. METHODS The study enrolled 49 adult patients with a diagnosis of mushroom poisoning according to clinical findings and 49 healthy volunteers as the control group. The patients with mild clinical findings were hospitalized due to the possibility that the patient had also eaten the mushrooms and due to clinical findings in the late period, which could be fatal. Paraoxonase, arylesterase, and glutathione-S-transferase concentrations, as well as total antioxidant and oxidant status, were determined in the 49 patients and 49 healthy volunteers by taking blood samples in the emergency department. RESULTS While paraoxonase, arylesterase, and total antioxidant status were significantly decreased in the patient group (p<0.05), glutathione-S-transferase, total oxidant status and the oxidative stress index were significantly higher (p<0.05). There was a positive correlation between the hospitalization time and the oxidative stress index (r=0.752, p<0.001), whereas a negative correlation was found with glutathione-S-transferase (r=-0.420, p=0.003). CONCLUSION We observed a significant decrease in paraoxonase and arylesterase and an increase in glutathione-S-transferase and oxidative stress indexes in patients with mushroom poisoning, indicating that these … |
| Anahtar Kelimeler |
| Antioxidant status | Emergency service | Hospitalization time | Mushroom poisoning | Oxidative stress |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 6 |
| Scopus | 6 |
| Google Scholar | 13 |