| Yazarlar |
Coşkun Silan
|
|
Ömer Tamer Doğan
Cumhuriyet Üniversitesi, Türkiye |
|
Fatma Silan
|
Prof. Dr. Fatma Mutlu KUKUL GÜVEN
Cumhuriyet Üniversitesi, Türkiye |
|
Halil Fatih Asgün
|
|
Semra Özdemir
|
|
Ahmet Uludağ
|
|
Sinem Atik
|
|
Buket Güngör
|
|
Seçil Akdur
|
|
Hakkı Engin Aksulu
|
|
Öztürk Özdemir
Çanakkale Onsekiz Mart Üniversitesi, Türkiye |
| Özet |
| The aim was to investigate the prevalence of VKORC1 and CYP2C9 genotypes in patients requiring anticoagulant therapy in two different region's populations of Turkey. The recent cohort included 292 patients that needed anticoagulant therapy, and who had a history of deep vein thrombosis and/or pulmonary artery thromboembolism. Genomic DNA was isolated from peripheral blood samples and the StripAssay reverse hybridization or Real Time PCR technique was used for genotype analysis. Genotypes for CYP2C9 were detected as follows: 165 (56.5 %) for CYP2C9*1/*1, 67 (23.0 %) for CYP2C9*1/*2, 25 (8.6 %) for CYP2C9*1/*3, 9 (3.0 %) for CYP2C9*2/*2, 21 (7.2 %) for CYP2C9*2/*3, 5(1.7 %) for CYP2C9*3/*3 for CYP2C9 and the allele frequencies were: 0.723 for allele*1, 0.182 for allele*2 and 0.095 for allele*3 respectively. Genotypes for VKORC1 were detected as follows: 64 (21.9 %) for GG, 220 (75.4 %) for GA and 8 (2.7 %) for AA alleles. The G allele frequency was detected as 0.596, and the A allele frequency was 0.404. The VKORC1 1639 G>A and CYP2C9 mutation prevalence and allele frequency of the current results from two different populations (Sivas and Canakkale) showed similarly very variable profiles when compared to the other results from the Turkish population. |
| Anahtar Kelimeler |
| VKORC1 1639 G < A | CYP2C9*2 and*3 SNP | Anticoagulant therapy | Allele frequency | Turkish population |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | MOLECULAR BIOLOGY REPORTS |
| Dergi ISSN | 0301-4851 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 12-2012 |
| Cilt No | 39 |
| Sayı | 12 |
| Sayfalar | 11017 / 11022 |
| Doi Numarası | 10.1007/s11033-012-2004-2 |
| Atıf Sayıları | |
| WoS | 5 |
