New perspectives into the chemical characterization of Sida acuta Burm. f. extracts with respect to its anti-cancer, antioxidant and enzyme inhibitory effects
Yazarlar (12)
Doç. Dr. Şengül Uysal Erciyes Üniversitesi, Türkiye
Reneta Gevrenova
Medical University Of Sofia, Bulgaristan
Kouadio Ibrahime Sinan
Selçuk Üniversitesi, Türkiye
Dr. Öğr. Üyesi Aslı Uğurlu Bayarslan Kastamonu Üniversitesi, Türkiye
Prof. Dr. Yasemin ÇELİK ALTUNOĞLU Kastamonu Üniversitesi, Türkiye
Dimitrina Zheleva-Dimitrova
Medical University Of Sofia, Bulgaristan
Doç. Dr. Güneş Ak Selçuk Üniversitesi, Türkiye
Prof. Dr. Mehmet Cengiz BALOĞLU Kastamonu Üniversitesi, Türkiye
Ouattara Katinan Etienne Université De Cocody-Abidjan
Devina Lobine
University Of Mauritius, Mauritius
Mohamad Fawzi Mahomoodally
University Of Mauritius, Mauritius
Prof. Dr. Gökhan Zengin Selçuk Üniversitesi, Türkiye
Makale Türü Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı Process Biochemistry (Q2)
Dergi ISSN 1359-5113 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili İngilizce Basım Tarihi 03-2021
Kabul Tarihi Yayınlanma Tarihi 01-06-2021
Cilt / Sayı / Sayfa 105 / 1 / 91–101 DOI 10.1016/j.procbio.2021.03.028
Makale Linki http://dx.doi.org/10.1016/j.procbio.2021.03.028
UAK Araştırma Alanları
Biyoteknoloji Moleküler Biyoloji
Özet
The chemical components, in vitro antioxidant capacities and enzyme inhibitory effects of dichloromethane (DCM), ethyl acetate (EA), methanol (MeOH) and water extracts of the medicinal plant, Sida acuta Burm. f. were evaluated. The individual phenolic components were assessed via ultra-high-performance liquid chromatography-high-resolution mass spectrometry (UHPLC-HRMS). In terms of chemical composition, phenolics (hydroxybenzoic and hydroxycinnamic acids) and flavonoids were identified as main groups. The antioxidant capacities were evaluated using a panoply of cell-free bioassays and the enzymatic inhibitory potentials against key enzymes involved in human diseases were also determined. The water extract exhibited the strongest scavenging abilities on DPPH (IC50: 1.05 mg/mL) and ABTS (IC50: 1.02 mg /mL). The best cholinesterase inhibitory abilities were observed with the methanol …
Anahtar Kelimeler
Anti-cancer | Bioactive compounds | Cholinesterase | Radical scavenging | Sida acuta | Solvents