| Yazarlar |
Kouadio Ibrahime Sinan
|
Dr. Öğr. Üyesi Uğur AKPULAT
Türkiye |
|
Afaf A. Aldahish
|
Prof. Dr. Yasemin ÇELİK ALTUNOĞLU
Kastamonu Üniversitesi, Türkiye |
Prof. Dr. Mehmet Cengiz BALOĞLU
Kastamonu Üniversitesi, Türkiye |
|
Dimitrina Zheleva-Dimitrova
|
|
Reneta Gevrenova
|
|
Devina Lobine
|
|
Fawzi Mahomoodally
|
|
Ouattara Katinan Etienne
|
|
Gökhan Zengin
Selçuk Üniversitesi, Türkiye |
|
Shafi Mahmud
|
|
Raffaele Capasso
|
| Özet |
| Boerhavia diffusa is a great tropical plant and is widely used for various traditional purposes. In the present study, we examined the influence of solvents (dichloromethane, ethyl acetate, methanol and infusion (water)) on chemical composition and biological capabilities of B. diffusa. An UHPLC-HRMS method was used to determine the chemical characterization. The biological ability was examined for antioxidant, enzyme inhibitory and anti-cancer effects. To evaluate antioxidant effects, different chemical methods (ABTS, DPPH, CUPRAC, FRAP, metal chelating and phosphomolybdenum) were applied. With regard to enzyme inhibitory properties, cholinesterases, amylase, glucosidase and tyrosinase were used. The MDA-MB-231 breast cancer cell line was chosen to determine anticancer activity. Based on the UHPLC-HRMS analysis, 37 specialized metabolites were dereplicated and identified in the studied extracts. Results revealed the presence of 15 hydroxybenzoic, hydroxycinnamic, acylquinic acids, and their glycosides, one rotenoid, seven flavonoids, 12 fatty acids and two other glycosides. Among the tested extracts, the methanol extract showed a stronger antioxidant ability compared with other extracts. The methanol extract also showed the best inhibitory effects on tyrosinase and glucosidase. In the anti-cancer evaluation, the methanol extract showed stronger anticancer effects compared with water extract. In summary, our observations can contribute to the establishment of B. diffusa as a potential candidate for functional applications in the preparation. |
| Anahtar Kelimeler |
| Anti-cancer | Antioxidant | Boerhavia diffusa | Enzyme inhibition | Flavonoids | Functional applications |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Antioxidants |
| Dergi ISSN | 2076-3921 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q1 |
| Makale Dili | İngilizce |
| Basım Tarihi | 12-2021 |
| Cilt No | 10 |
| Sayı | 12 |
| Doi Numarası | 10.3390/antiox10122003 |
| Makale Linki | http://dx.doi.org/10.3390/antiox10122003 |
| Atıf Sayıları | |
| SCOPUS | 34 |
| Google Scholar | 1 |
