| Yazarlar |
M Fawzi Mahomoodally
|
|
Elwira Sieniawska
|
|
Kouadio Ibrahime Sinan
|
|
Picot-Allain Marie Nancy
|
|
Serife Yerlikaya
|
Prof. Dr. Mehmet Cengiz BALOĞLU
Kastamonu Üniversitesi, Türkiye |
Prof. Dr. Yasemin ÇELİK ALTUNOĞLU
Kastamonu Üniversitesi, Türkiye |
|
Ismail Senkardes
|
|
Kannan Rr Rengasamy
|
|
Gökhan Zengin
Selçuk Üniversitesi, Türkiye |
| Özet |
| Ethnobotanical evidences report the use of Rhododendron luteum Sweet (Ericaceae) in traditional medicinal systems. However, R. luteum has been associated to the occurrence of ‘mad honey’ poisoning. In the present study, the ethyl acetate, methanol, and water extracts of R. luteum were investigated for their in vitro antioxidant, enzyme inhibition, and cytotoxic properties. The cytotoxicity of R. luteum extracts on A549 lung cancer cell line was evaluated using MTT cell viability assay. Besides, HPLC-ESI-MSn approach was employed to elucidate the secondary metabolite profiles of R. luteum in order to establish any structure-activity relationship. Methanol and water extracts of R. luteum possessed highest radical scavenging and reducing properties while the ethyl acetate extract showed highest metal chelating properties. In terms of enzyme inhibition, the methanol and ethyl acetate extracts of R. luteum, possessing epigallocatechin, were active inhibitors of cholinesterase enzymes, α-glucosidase, and tyrosinase. Water extract caused growth inhibition of A549 cells with 207.2 μg/ml IC50 value. Though R. luteum has received little scientific attention due to the occurrence of grayanotoxins in the plant, however, data presented in this work shows promising biological activity of R. luteum and highlighted its role as a potential source of antioxidant and key enzyme inhibitors. |
| Anahtar Kelimeler |
| Anticancer | Enzyme inhibitory | Honeysuckle azalea | PCA analysis | Yellow azalea |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Food and Chemical Toxicology |
| Dergi ISSN | 0278-6915 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2020 |
| Cilt No | 135 |
| Sayı | 1 |
| Sayfalar | 111052 / 0 |
| Doi Numarası | 10.1016/j.fct.2019.111052 |
| Makale Linki | https://linkinghub.elsevier.com/retrieve/pii/S0278691519308427 |
| Atıf Sayıları | |
| SCOPUS | 14 |
| Google Scholar | 25 |
