| Yazarlar |
Gökhan Zengin
Selçuk Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Aslı UĞURLU BAYARSLAN
Kastamonu Üniversitesi, Türkiye |
Prof. Dr. Mehmet Cengiz BALOĞLU
Kastamonu Üniversitesi, Türkiye |
|
Alina Diuzheva
|
|
Jeko Jozsef
|
|
Cziaky Zoltan
|
|
Ramazan Ceylan
|
|
Abdurrahman Aktümsek
Selçuk Üniversitesi, Türkiye |
|
Carene Marie Nancy Picot Allain
|
|
Fawzi Mahomoodally
|
| Özet |
| This study was geared towards assessing the possible antioxidant, enzyme inhibitory, and cytotoxic activities of ethyl acetate, methanol, and water extracts of Sideritis ozturkii Aytaç & Aksoy. The phytochemical profiles of the studied extracts were characterised by HPLC-MS/MS. The methanol extract, rich in phenolics (78.04 mg gallic acid equivalent/g), exhibited the strongest antioxidant activities. However, the ethyl acetate extract was the most active extract in the enzyme inhibitory assays. The water extract of S. ozturkii (1 mg/ml, 48 h incubation) slightly inhibited (22%) growth of human breast cancer cell line (MDA-MB-231 cells). On the other hand, the ethyl acetate and methanol extracts showed strong inhibition (98% and 97%, respectively) of MDA-MB-231 cells and caused apoptotic cell death. Scientific data generated from this study further appraises the multiple biological activities of plants belonging to the Sideritis genus. In addition, preliminary evidence gathered from the current investigation advocates for further studies geared towards the preparation of therapeutic formulations from S. ozturkii. |
| Anahtar Kelimeler |
| Antioxidant | Apoptosis | Bioactive agents | Diabetes | Neuroprotection | Sideritis |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Journal of Pharmaceutical and Biomedical Analysis |
| Dergi ISSN | 0731-7085 |
| Dergi Tarandığı Indeksler | SCI |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 04-2019 |
| Cilt No | 171 |
| Sayı | 171 |
| Sayfalar | 118 / 125 |
| Doi Numarası | 10.1016/j.jpba.2019.04.011 |
| Makale Linki | https://www.sciencedirect.com/science/article/abs/pii/S0731708519302973?via3Dihub |
| Atıf Sayıları | |
| SCOPUS | 18 |
| Google Scholar | 23 |
