Investigation of chemical profile, biological properties of Lotus corniculatus L. extracts and their apoptotic-autophagic effects on breast cancer cells
Yazarlar (6)
Dr. Öğr. Üyesi Serife Yerlikaya Kastamonu Üniversitesi, Türkiye
Prof. Dr. Mehmet Cengiz BALOĞLU Kastamonu Üniversitesi, Türkiye
Alina Diuzheva Pavol Jozef Šafárik University İn Košice, Slovakya
József Jekő University Of Nyíregyháza, Macaristan
Zoltán Cziáky University Of Nyíregyháza, Macaristan
Prof. Dr. Gokhan Zengin Selçuk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Pharmaceutical and Biomedical Analysis (Q2) | ||
| Dergi ISSN | 0731-7085 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2019 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-09-2019 |
| Cilt / Sayı / Sayfa | 174 / 1 / 286–299 | DOI | 10.1016/j.jpba.2019.05.068 |
| Makale Linki | https://www.sciencedirect.com/science/article/abs/pii/S0731708519311239 | ||
| UAK Araştırma Alanları |
Biyoteknoloji
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| Özet |
| This study aimed to reveal chemical profiles and biological activities of ethyl acetate (EA), methanol (MeOH), and water extracts of Lotus corniculatus. Ethnobotanical reports have indicated the importance of phytochemical properties of the genus Lotus. In this study, the effects of medicinal plant extracts on antioxidant (DPPH, ABTS, CUPRAC, FRAP, phosphomolybdenum, and metal chelating assays), enzyme inhibitory (on cholinesterase, tyrosinase, a-amylase and a-glucosidase), DNA protection and anticancer properties (including anti-proliferative, cell death and telomerase activity marker gene analysis, apoptotic DNA fragmentation analysis, cell migration test) were evaluated.According to chemical analysis, quercetin derivatives geraldol, isorhamnetin and kaempferol-O-coumaroylhexoside-O-deoxyhexoside isomers were dominant in the extracts. MeOH extracts showed the highest total flavonoids capacity with … |
| Anahtar Kelimeler |
| Apoptosis | Autophagy | Chemical ingredients | Extracts | Lotus |
Science Direct
Investigation of chemical profile, biological properties of Lotus corniculatus L. extracts and their apoptotic-autophagic effects on breast cancer cells
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 35 |
| Google Scholar | 44 |