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Medicine designed to combat diseases of affluence affects the early development of fish. How do plastic microparticles contribute?        
Yazarlar (14)
Denisa Medkova
Veterinární Univerzita Brno, Çek Cumhuriyeti
Aneta Hollerova
Veterinární Univerzita Brno, Çek Cumhuriyeti
Jana Blahova
Veterinární Univerzita Brno, Çek Cumhuriyeti
Petr Marsalek
Veterinární Univerzita Brno, Çek Cumhuriyeti
Jan Mares
Mendelova Univerzita V Brně, Çek Cumhuriyeti
Nikola Hodkovicova
Veterinary Research Institute, Brno, Çek Cumhuriyeti
Veronika Doubkova
Veterinární Univerzita Brno, Çek Cumhuriyeti
Renata Hesova
Veterinární Univerzita Brno, Çek Cumhuriyeti
Frantisek Tichy
Veterinární Univerzita Brno, Çek Cumhuriyeti
Martin Faldyna
Veterinary Research Institute, Brno, Çek Cumhuriyeti
Arş. Gör. Dr. Yiğit TAŞTAN Arş. Gör. Dr. Yiğit TAŞTAN
Kastamonu Üniversitesi, Türkiye
Jan Kotoucek
Veterinary Research Institute, Brno, Çek Cumhuriyeti
Zdenka Svobodova
Veterinární Univerzita Brno, Çek Cumhuriyeti
Pavla Lakdawala
Veterinární Univerzita Brno, Çek Cumhuriyeti
Devamını Göster
Özet
The incidence of diseases of affluence, such as diabetes mellitus, cardiovascular diseases, high blood pressure, and high cholesterol has been reported to rise. Consequently, the concentrations of residues of drugs designed to treat these diseases have been rising in water bodies. Moreover, the toxicity of these pharmaceuticals towards fish and other non-target organisms can be even enhanced by microplastic particles that are reportedly present in surface water. Therefore, the aim of this study was to describe the effects of three highly prescribed drugs, in particular metoprolol, enalapril, and metformin on fish early-life stages. Also, it was hypothesized that polystyrene microparticles will increase the toxicity of metoprolol to fish early-life stages. Embryonal acute toxicity tests on Danio rerio and Cyprinus carpio were carried out in order to describe the possible toxic effects of metoprolol, enalapril, and metformin. Also, the acute toxicity of polystyrene microparticles and the combination of metoprolol with polystyrene microparticles were tested on D. rerio embryos. Additionally, a 31-day long embryo-larval subchronic toxicity test was carried out with C. carpio in order to describe the long-term effects of low concentrations of metoprolol. The results of the study show that both metoprolol and enalapril have the potential to disrupt the early development of the heart in the embryonal stages of fish. Also, enalapril and metformin together with polystyrene microparticles seem to possibly disrupt the reproduction cycle and act as endocrine disruptors. Both pure polystyrene microparticles and the combination of them with metoprolol affect inflammatory processes in organisms. Additionally, metformin alters several metabolism pathways in fish early-life stages. The results of the study bring new evidence that even low, environmentally-relevant concentrations of pharmaceuticals have the potential to disrupt the early development of fish, particularly on a molecular level.
Anahtar Kelimeler
Cyprinus carpio | Danio rerio | Enalapril | Metformin | Metoprolol
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale
Dergi Adı SCIENCE OF THE TOTAL ENVIRONMENT
Dergi ISSN 0048-9697 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler SCI-Expanded
Dergi Grubu Q1
Makale Dili İngilizce
Basım Tarihi 12-2023
Cilt No 904
Sayı 1
Doi Numarası 10.1016/j.scitotenv.2023.166378
Makale Linki https://doi.org/10.1016/j.scitotenv.2023.166378