Plasma and muscle tissue disposition of enrofloxacin in Nile tilapia (Oreochromis niloticus) after intravascular, intraperitoneal, and oral administrations
Yazarlar (11)
Prof. Dr. Orhan Çorum University Of Hatay Mustafa Kemal, Türkiye
Doç. Dr. Ertuğrul TERZİ Kastamonu Üniversitesi, Türkiye
Doç. Dr. Duygu Durna Çorum University Of Hatay Mustafa Kemal, Türkiye
Arş. Gör. Dr. Yiğit TAŞTAN Kastamonu Üniversitesi, Türkiye
Ruby C Gonzales
Mindanao State University At Naawan, Filipinler
Mindanao State University At Naawan, Filipinler
Arş. Gör. Dr. Osman Nezih KENANOĞLU Kastamonu Üniversitesi, Türkiye
Dan M Arriesgado
Mindanao State University At Naawan, Filipinler
Mindanao State University At Naawan, Filipinler
Victor R Navarro
Mindanao State University At Naawan, Filipinler
Mindanao State University At Naawan, Filipinler
Doç. Dr. Soner BİLEN Kastamonu Üniversitesi, Türkiye
Doç. Dr. Adem Yavuz SÖNMEZ Kastamonu Üniversitesi, Türkiye
Prof. Dr. Kamil Üney Selçuk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Food Additives and Contaminants Part A (Q2) | ||
| Dergi ISSN | 1944-0049 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 09-2022 |
| Kabul Tarihi | 28-08-2022 | Yayınlanma Tarihi | 22-09-2022 |
| Cilt / Sayı / Sayfa | 39 / 11 / 1806–1817 | DOI | 10.1080/19440049.2022.2121429 |
| Makale Linki | http://dx.doi.org/10.1080/19440049.2022.2121429 | ||
| UAK Araştırma Alanları |
Su Ürünleri Yetiştiriciliği
Su Ürünleri Hastalıkları
|
||
| Özet |
| The aim of the study was to investigate the plasma and muscle pharmacokinetic of enrofloxacin (ENR) and its active metabolite ciprofloxacin (CIP) in Nile tilapia (Oreochromis niloticus) following single intravascular (IV), intraperitoneal (IP), or oral (PO) administration at 30 ± 1 °C. In this study, 234 healthy Nile tilapia (120–150 g) were used. The fish received a single IV, IP, or PO treatment of ENR at a dose of 10 mg/kg. The plasma and muscle tissue concentrations of ENR and CIP were measured using high–performance liquid chromatography with fluorescence detection and were evaluated using non–compartmental analysis. The elimination half–life, volume of distribution at steady state, and total body clearance of ENR were 21.7 h, 2.69 L/kg, and 0.09 L/h/kg, respectively. The peak plasma concentrations of ENR after IP or PO administration were 6.11 and 4.21 µg/mL at 0.25 and 2 h, respectively. The … |
| Anahtar Kelimeler |
| bioavailability | enrofloxacin | muscle tissue | Pharmacokinetics | rainbow trout |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 20 |
| Scopus | 21 |
| Google Scholar | 19 |