Tauroursodeoxycholic Acid (TUDCA) Regulates Inflammation and Hypoxia in Autonomic Tissues of Rats with Seizures
Yazarlar (11)
Arda Kaan Üner
Yozgat Bozok University, Türkiye
Yozgat Bozok University, Türkiye
Aslı Okan
Yozgat Bozok University, Türkiye
Yozgat Bozok University, Türkiye
Enes Akyüz University Of Health Sciences, Türkiye
Betül Köklü
Tekirdağ Namık Kemal Üniversitesi, Türkiye
Tekirdağ Namık Kemal Üniversitesi, Türkiye
Arş. Gör. Ece Eroğlu Yozgat Bozok University, Türkiye
Seher Yilmaz Yozgat Bozok University, Türkiye
Dr. Öğr. Üyesi Demet ÜNALMIŞ AYKAR Kastamonu Üniversitesi, Türkiye
Emin Kaymak Yozgat Bozok University, Türkiye
Feyza Şule Aslan
University Of Health Sciences, Türkiye
University Of Health Sciences, Türkiye
Muhammad Zahid Qureshi
Qassim University, Suudi Arabistan
Qassim University, Suudi Arabistan
Züleyha Doğanyiğit Yozgat Bozok University, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Cellular and Molecular Biology (Q4) | ||
| Dergi ISSN | 0145-5680 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 04-2023 |
| Cilt / Sayı / Sayfa | 68 / 12 / 104–111 | DOI | 10.14715/CMB/2022.68.12.19 |
| Makale Linki | http://dx.doi.org/10.14715/cmb/2022.68.12.19 | ||
| UAK Araştırma Alanları |
Histoloji ve Embriyoloji
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| Özet |
| Inflammation and hypoxia have an effect on the molecular mechanism of cardiovascular and respiratory pathologies accompanying seizures. Against this, Tauroursodeoxycholic Acid (TUDCA) can regulate oxidative stress, inflammation and cellular survival by suppressing endoplasmic reticulum (ER) stress. We evaluated the expression changes of NF-κB p65, TNF-α, HIF1α and Kir6. 2 proteins associated with seizures in brain stem, heart and lung tissues representing the autonomous network. Additionally, we examined the protective effects of TUDCA administration against damage caused by seizures in terms of immunohistochemistry and pathology. 4 groups of Wistar Albino male rats (250-300 g, n= 32) were formed as control, pentylenetetrazole (PTZ), TUDCA and PTZ+ TUDCA. The epilepsy kindling model was created by intraperitoneal (ip) injection of PTZ chemical (35 mg/kg, every 2 days) for one month. TUDCA (500 mg/kg; every 2 days) treatment was given intraperitoneally 30 minutes before seizures for 1 month. Brain stem, heart (atria, ventricle) and lung tissues of rats were isolated. NF-κB p65, TNF-α, HIF1α and Kir6. 2 proteins in the obtained tissues were evaluated by immunohistochemical staining. The immunoreactivity of the investigated proteins in the brainstem heart and lung tissues of rats with chronic PTZ administration was significantly increased. Recurrent seizures led to accumulation of inflammatory cells in tissues, hemorrhage, vasodilation, and apoptosis. Following TUDCA administration, expression of NF-κB p65, TNF-α and Kir6. 2 was significantly reduced in all tissues (except the atrium of the heart) compared to control … |
| Anahtar Kelimeler |
| HIF1α | Kir6.2 | NF-κB p65 | PTZ | TNF-α |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 3 |
| Scopus | 4 |
| Google Scholar | 4 |