Tenotomy immobilization as a model to investigate skeletal muscle fibrosis (with emphasis on Secreted frizzled-related protein 2)
Yazarlar (3)
Doç. Dr. Uğur AKPULAT Kastamonu Üniversitesi, Türkiye
İlyas Onbaşılar Hacettepe Üniversitesi, Türkiye
Y. Çetin Kocaefe Hacettepe Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Physiological Genomics (Q2) | ||
| Dergi ISSN | 1094-8341 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2016 |
| Cilt / Sayı / Sayfa | 48 / 6 / 397–408 | DOI | 10.1152/physiolgenomics.00010.2016 |
| Makale Linki | https://journals.physiology.org/doi/full/10.1152/physiolgenomics.00010.2016 | ||
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| The pathological endpoint of congenital and senile myopathies is chronic muscle degeneration characterized by the atrophy of contractile elements, accompanied by fibrosis and fatty infiltration of the interstitium. Tenotomy is the release of preload that causes abrupt shortening of the muscle and models atrophy and fibrosis without prominent inflammatory response. Fibrosis in the skeletal muscle is known to be triggered by transforming growth factor (TGF)-β, which is activated by inflammatory events. As these were lacking, tenotomy provided an opportunity to investigate transcriptional events on a background without inflammation. An unbiased look at the transcriptome of tenotomy-immobilized soleus muscle revealed that the majority of the transcriptional changes took place in the first 4 wk. Regarding atrophy, proteasomal and lysosomal pathways were actively involved in accompanying cathepsins and calpains in … |
| Anahtar Kelimeler |
| Fibrosis | Immobilization | Muscle atrophy | Sfrp2 | Tenotomy |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 10 |
| Scopus | 10 |
| Google Scholar | 15 |