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The role of Dopamine 2 receptor gene and personality characteristics in alcohol dependence in Turkish population     
Yazarlar
Dalmış Arzu
Yıldız Akvardar
Marmara Üniversitesi, Türkiye
Çiğdem Eresen Yazıcıoğlu
Dokuz Eylül Üniversitesi, Türkiye
Sefa Kızıldağ
Dokuz Eylül Üniversitesi, Türkiye
Dr. Öğr. Üyesi Uğur AKPULAT
Kastamonu Üniversitesi, Türkiye
Şebnem Yıldırımcan Kadıçeşme
Kafkas Üniversitesi, Türkiye
Özet
Objective: Focusing on dopaminergic system, which is regarded to be responsible for alcohol dependence in many studies on animals and human beings, it is aimed to investigate TaqI A and B allel polymorphisms of dopa-mine 2 receptor and personality characteristics in alcohol dependents and the relationship between these two parameters. Methods: In this study 64 alcohol dependent patients (3 females, 61 males) diagnosed according to DSM-IV diagnosis criteria, and 54 healthy subjects (8 females, 46 males) who themselves or whose first or second degree relatives had no alcohol dependence history were included. In order to determine their TaqI A and B alleles, blood samples were drawn from the participants, and then they were applied Temperament and Character Inventory and Michigan Alcoholism Screening Test. Results: Subjects with and without alcohol dependence revealed no significant difference as regards the frequency of TaqI A1 and B2 minor allel polymorphisms of DRD2gene. It was also determined that the alcohol dependents had significantly higher scores in novelty seeking and harm avoidance dimensions, and lower scores in self directedness and cooperativeness dimensions than the controls. In alcohol dependents, no association was determined between the personality characteristics and TaqI A1 and B2 minor allel polymorphisms. Conclusion: Not only one gene, but also several other minor genes in addition to personality characteristics and environment may play a role in vulnerability to alcohol dependence. In alcohol dependents, high novelty seeking is associated with the increase in impulsive behavior, and may be important for the onset of alcohol taking behavior. High level of harm avoidance may lead to taking alcohol continuously in order to deal with stress.
Anahtar Kelimeler
Alcohol dependence,genetics,D-2 dopamine receptor gene (DRD2),Temperament and Character Inventory,personality
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı Anatolian Journal of Psychiatry
Dergi ISSN 1302-6631
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili İngilizce
Basım Tarihi 01-2013
Cilt No 15
Sayı 3
Sayfalar 1 / 199
Doi Numarası 10.5455/apd.44724
Makale Linki http://www.scopemed.org/?mno=44724