The vasorelaxant effect of hydrogen sulfide is enhanced in streptozotocin-induced diabetic rats
Yazarlar (5)
Merve Denizalti Hacettepe Üniversitesi, Türkiye
Turgut Emrah Bozkurt Hacettepe Üniversitesi, Türkiye
Doç. Dr. Uğur AKPULAT Hacettepe Üniversitesi, Türkiye
Inci Sahin-Erdemli Hacettepe Üniversitesi, Türkiye
Nurettin Abacioǧlu Gazi Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Naunyn Schmiedeberg S Archives of Pharmacology (Q2) | ||
| Dergi ISSN | 0028-1298 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2011 |
| Cilt / Sayı / Sayfa | 383 / 5 / 509–517 | DOI | 10.1007/s00210-011-0601-6 |
| Makale Linki | https://link.springer.com/article/10.1007/s00210-011-0601-6 | ||
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| Hydrogen sulfide (H2S) is an endogenous gas which has potent relaxant effect in vascular and nonvascular smooth muscles. In the present study, we have investigated how streptozotocin (STZ)-induced diabetes affected the relaxant effect of H2S in rat isolated thoracic aorta and mesenteric and pulmonary arteries. Diabetes was induced by IV injection of STZ (35 mg/kg). Insulin treatment was applied by using insulin implants. At the end of 4 and 12 weeks, the thoracic aorta and mesenteric and pulmonary arteries were isolated, and the relaxation responses to sodium hydrogen sulfide (NaHS), diazoxide, and acetylcholine were evaluated. The mRNA and protein levels of H2S-synthesizing enzymes were also examined by RT-PCR and Western Blot. The relaxation response to NaHS in the arteries isolated from both 4 and 12 week-diabetic rats was increased when compared with that obtained from the control group … |
| Anahtar Kelimeler |
| Diabetes | Hydrogen sulfide | In vitro | Relaxation | Vascular smooth muscle |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 25 |
| Scopus | 29 |
| Google Scholar | 32 |