Upregulation and the clinical significance of KCNQ1OT1 and HAGLROS lncRNAs in papillary thyroid cancer: An observational study
Yazarlar (6)
Doç. Dr. Fadime Mutlu İçduygu Giresun Üniversitesi, Türkiye
Dr. Öğr. Üyesi Egemen Akgün Giresun Üniversitesi, Türkiye
Doç. Dr. Asuman ÖZGÖZ Kastamonu Üniversitesi, Türkiye
Doç. Dr. Kuyaş Hekimler Öztürk Süleyman Demirel University, Faculty Of Medicine, Türkiye
Prof. Dr. Demet Şengül Giresun Üniversitesi, Türkiye
Prof. Dr. Ebru Alp Giresun Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Medicine United States (Q2) | ||
| Dergi ISSN | 0025-7974 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 07-2023 |
| Cilt / Sayı / Sayfa | 102 / 29 / – | DOI | 10.1097/MD.0000000000034379 |
| Makale Linki | http://dx.doi.org/10.1097/md.0000000000034379 | ||
| UAK Araştırma Alanları |
Tıbbi Genetik
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| Özet |
| Long noncoding RNAs (lncRNAs) play an important role in regulating gene expression. Changes in their expression have been associated with many types of cancer, including thyroid cancer. This study aimed to investigate how changes in the expression of potassium voltage-gated channel subfamily Q member 1 opposite strand/antisense transcript 1 (KCNQ1OT1) and HAGLR opposite strand lncRNA (HAGLROS) lncRNAs correlate with the development and clinicopathological characteristics of papillary thyroid cancer (PTC). Reverse transcription-quantitative polymerase chain reaction was used to investigate the expression of lncRNAs in both tumor and adjacent normal thyroid tissue samples of the patients. Expressions of KCNQ1OT1 and HAGLROS were upregulated in the patients tumor samples compared to the adjacent normal thyroid samples. KCNQ1OT1 expression was linked to microcarcinoma and gender, while HAGLROS expression was linked to microcarcinoma and tumor size. When only microcarcinoma samples were evaluated, KCNQ1OT1 expression was higher in tumor tissues compared to normal tissues; however, no significant difference was observed in HAGLROS expression. Our data suggests that high expressions of KCNQ1OT1 and HAGLROS might contribute to the development of PTC and disease progression, and both lncRNAs may be potential therapeutic targets in PTC patients. |
| Anahtar Kelimeler |
| gene expression | HAGLROS | KCNQ1OT1 | long noncoding RNA | microcarcinoma | papillary thyroid cancer |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 5 |