POSTMENOPAUSAL ESTROGEN RECEPTOR POSITIVE BREAST CANCER AND OBESITY ASSOCIATED GENE VARIANTS
Yazarlar (7)
Doç. Dr. Asuman ÖZGÖZ Kastamonu Üniversitesi, Türkiye
Doç. Dr. Fadime Mutlu İçduygu Giresun Üniversitesi, Türkiye
Ayşegül Yükseltürk
Kastamonu Üniversitesi, Türkiye
Kastamonu Üniversitesi, Türkiye
Hale Şamlı Bursa Uludağ Üniversitesi, Türkiye
Doç. Dr. Kuyaş Hekimler Öztürk Süleyman Demirel Üniversitesi, Türkiye
Zuhal Başkan
Acibadem Bursa Hospital, Türkiye
Acibadem Bursa Hospital, Türkiye
İlknur Tütüncü
Kastamonu Üniversitesi, Türkiye
Kastamonu Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Excli Journal (Q1) | ||
| Dergi ISSN | 1611-2156 Dergi Bilgileri (2021) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2021 |
| Cilt / Sayı / Sayfa | 20 / 1 / 1133–1144 | DOI | 10.17179/excli2020-2860 |
| UAK Araştırma Alanları |
Tıbbi Genetik
|
||
| Özet |
| Obesity is one of the most important health risks in postmenopausal women. Molecular pathways that are connected with obesity are believed to interact with the pathogenesis of breast cancer (BC). The aim of this research was to study the polymorphisms of two obesity-associated genes ADIPOQ and FTO that are also related to the pathogenesis of BC. Obesity-associated gene polymorphisms ADIPOQ rs1501299 and rs2241766, and FTO rs1477196, rs7206790, rs8047395, and rs9939609 were studied in 101 Turkish postmenopausal estrogen receptor-positive BC patients and 100 healthy control individuals. ADIPOQ rs1501299 was detected to be associated with protection against BC. The ADIPOQ rs1501299 TT genotype, the rs2241766 GT genotype and the G allele were found to be significantly higher in the control group. In addition, ADIPOQ rs1501299 polymorphism was protective in the recessive model … |
| Anahtar Kelimeler |
| ADIPOQ | Breast cancer | FTO | Polymorphism | Postmenopausal |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 4 |
| Scopus | 5 |