| Yazarlar |
Fadime Mutlu İçduygu
Giresun Üniversitesi, Türkiye |
|
Egemen Akgün
Giresun Üniversitesi, Türkiye |
|
Demet Şengül
Türkiye |
Doç. Dr. Asuman ÖZGÖZ
Kastamonu Üniversitesi, Türkiye |
|
Ebru Alp
Giresun Üniversitesi, Türkiye |
| Özet |
| Long non-coding RNAs (lncRNAs) are molecules that are >200 base pairs long and do not encode a protein. However, they perform important roles in regulating gene expression. Recent studies have revealed that the changes in the expressions of lncRNAs serve a role in the development and metastases of a number of types of cancer. A number of studies have been published on the association of SOX2 overlapping transcript (SOX2OT), differentiation antagonizing non-protein coding RNA (DANCR) and tissue differentiation-induced non-coding RNA (TINCR) expression with various types of cancer. However, researchers have not yet studied their roles in papillary thyroid cancer or at least, those roles are not clarified. The aim of the present study was to investigate the expression and clinical significance of SOX2OT, DANCR and TINCR in papillary thyroid cancer (PTC). A total of 102 patients with PTC were included in the present study. Reverse transcription-quantitative PCR method was used to determine the relative gene expression levels of lncRNAs and then the relationship between expressions of lncRNAs and clinical characteristics of the subjects was analyzed in detail. Expression levels of SOX2OT (P=0.016) and DANCR (P=0.017) increased in the tumor samples in contrast to the normal tissues. No significant difference was observed in the expression level of TINCR (P=0.298). In addition, SOX2OT expression was associated with micro carcinoma (P<0.001), tumor size (P=0.010) and primary tumor (P=0.006), while DANCR expression was associated with age (P=0.030) and micro carcinoma (P=0.004). The findings of the present study indicated that DANCR may contribute to the development of PTC while SOX2OT may contribute to both the development and progression of PTC. |
| Anahtar Kelimeler |
| Differentiation antagonizing non-protein coding RNA | Long non-coding RNA | Papillary thyroid cancer | Reverse transcription-quantitative PC | SOX2 overlapping transcript | Tissue differentiation-induced non-coding RNA |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Molecular Medicine Reports |
| Dergi ISSN | 1791-2997 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q3 |
| Makale Dili | Türkçe |
| Basım Tarihi | 04-2022 |
| Cilt No | 25 |
| Sayı | 4 |
| Sayfalar | 120 / 0 |
| Doi Numarası | 10.3892/mmr.2022.12636 |
| Makale Linki | http://dx.doi.org/10.3892/mmr.2022.12636 |
| Atıf Sayıları | |
| SCOPUS | 5 |
