Genetic Variations of DNA Repair Genes in Breast Cancer
Yazarlar (7)
Doç. Dr. Asuman ÖZGÖZ Kastamonu Üniversitesi, Türkiye
Doç. Dr. Kuyaş Hekimler Öztürk Süleyman Demirel Üniversitesi, Türkiye
Ayşegül Yükseltürk
Kastamonu Üniversitesi, Türkiye
Kastamonu Üniversitesi, Türkiye
Prof. Dr. Hale Şamlı Uludağ Üniversitesi, Türkiye
Zuhal Başkan Acıbadem Mehmet Ali Aydınlar Üniversitesi, Türkiye
Doç. Dr. Fadime Mutlu İçduygu Giresun Üniversitesi, Türkiye
Mehmet Bacaksız
Alanya Çıplaklı Family Health Center, Türkiye
Alanya Çıplaklı Family Health Center, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Pathology and Oncology Research (Q2) | ||
| Dergi ISSN | 1219-4956 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2019 |
| Cilt / Sayı / Sayfa | 25 / 1 / 107–114 | DOI | 10.1007/s12253-017-0322-3 |
| Makale Linki | http://link.springer.com/10.1007/s12253-017-0322-3 | ||
| UAK Araştırma Alanları |
Tıbbi Genetik
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| Özet |
| Genetic variations in DNA repair genes may affect DNA repair capacity therefore increase risk for cancer. In our study, we evaluted the relation between DNA repair gene polymorphisms XRCC1 rs1799782, rs25487, rs25489; XPC rs2228000, rs2228001; XPD rs1799793, rs13181; XRCC3 rs861539; RAD51B rs10483813, rs1314913 and breast cancer risk for 202 Turkish cases in total, in which 102 patients with breast cancer and 100 controls. Genotyping of the DNA samples was carried out by multiplex PCR and matrix-assisted laser desorption/ionization mass spectrometry with time of flight measurement (MALDI-TOF) using Sequenom MassARRAY 4 analyzer. Genotype and allele distributions were calculated between the groups. Odds ratios (ORs) and 95% confidence intervals (CIs) were reported. rs25487 AA genotype and A allele was found to be increased in the control group (respectively, OR 0.16 95% CI 0.02–1.06, p = 0.058; OR 1.55, 95% CI 1.01–2.36, p = 0.043) and rs861539 T allele was found to be decreased in the patient group (OR 1.53, 95% CI 1.01–2.30, p = 0.049). No association with breast cancer was found for the remaining SNPs. Our findings suggest that XRCC1 rs25487 AA genotype and A allele, XRCC3 rs861539 T allele may have protective effects in breast cancer for Turkish population. |
| Anahtar Kelimeler |
| Breast cancer | DNA damage | DNA repair | Polymorphism |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 17 |