img
Surgery for acute abdomen and MEFV mutations in patients with FMF    
Yazarlar
Hale Şamlı
Bursa Uludağ Üniversitesi, Türkiye
Fadime Mutlu İçduygu
Giresun Üniversitesi, Türkiye
Doç. Dr. Asuman ÖZGÖZ
Kastamonu Üniversitesi, Türkiye
Gökhan Akbulut
İzmir Tınaztepe Üniversitesi, Türkiye
Kuyaş Hekimler Öztürk
Süleyman Demirel Üniversitesi, Türkiye
Necat İmirzalıoğlu
Girne Üniversitesi, Türkiye
Özet
Objectives: Familial Mediterranean Fever (FMF) is an autosomal recessive disease characterized by recurrent fever, peritonitis, arthritis, pleuritis, and secondary amyloidosis. In the current study, we sought to determine the frequency of acute surgical abdominal intervention and MEFV gene mutations in FMF patients. Patients and Methods: A total of 159 patients were referred to our department with a diagnosis of FMF. Twenty-six patients (16.4%) had a history of surgical intervention. Of these, 17 (10.7%) were operated on due to appendicitis, and 9 (5.7%) were operated on due to other acute abdomen reasons. Genomic DNA was isolated from the blood samples, and in the isolated DNA samples, 12 MEFV gene mutations were studied. Results: Mutation frequency was detected to be 80.8% in the patients with acute abdomen surgery intervention and 56.4% in the patients without acute abdomen surgical intervention. Upon mutational evaluation of these patients, we noted that the M694V (40.5%) and E148Q (21.4%) mutations occurred most frequently. Conclusions: The MEFV gene mutation frequency in FMF patients with acute abdomen surgical intervention was significantly higher than that in patients without such intervention. Increased mutation scanning in FMF patients will significantly decrease unnecessary surgical interventions in this patient group.
Anahtar Kelimeler
Acute abdomen | FMF | Genetic mutations
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı Acta Reumatólogica Portuguesa
Dergi ISSN 0303-464X
Dergi Tarandığı Indeksler SCI-Expanded
Dergi Grubu Q4
Makale Dili İngilizce
Basım Tarihi 01-2009
Cilt No 34
Sayı 3
Sayfalar 520 / 524
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
SCOPUS 6

Paylaş