An investigation of the effects of FGFR2 and B7 H4 polymorhisms in breast cancer
Yazarlar (6)
Doç. Dr. Asuman ÖZGÖZ Kastamonu Üniversitesi, Türkiye
Hale Şamlı Bursa Uludağ Üniversitesi, Türkiye
Doç. Dr. Kuyaş Hekimler Öztürk Süleyman Demirel Üniversitesi, Türkiye
Bülent Orhan
Acıbadem Mehmet Ali Aydınlar Üniversitesi, Türkiye
Acıbadem Mehmet Ali Aydınlar Üniversitesi, Türkiye
Doç. Dr. Fadime Mutlu İçduygu Giresun Üniversitesi, Türkiye
Fatma Aktepe
Afyon Kocatepe Üniversitesi, Türkiye
Afyon Kocatepe Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Journal of Cancer Research and Therapeutics (Q4) | ||
| Dergi ISSN | 0973-1482 Dergi Bilgileri (2013) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2013 |
| Cilt / Sayı / Sayfa | 9 / 3 / 370–375 | DOI | 10.4103/0973-1482.114434 |
| Makale Linki | https://www.cancerjournal.net/article.asp?issn=0973-1482;year=2013;volume=9;issue=3;spage=370;epage=375;aulast=%D6zg%F6z | ||
| UAK Araştırma Alanları |
Tıbbi Genetik
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| Özet |
| Materials and Methods:In a group of 31 cases diagnosed with breast cancer and 30 healthy women with matched ages, the single-nucleotide polymorphisms (SNPs) rs1219648, rs2981582 in FGFR2 gene were identified by sequence analysis and the SNPs rs10754339, rs10801935, and rs3738414 in the B7-H4 gene were identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Statistical analysis was performed using SPSS.Results:Although statistically not significant, the frequency of FGFR2 heterozygous polymorphisms in the group with breast cancer was detected to be higher. In the B7-H4 SNP rs10801935, polymorphic AA, and AG genotype distributions were found in higher frequencies in the breast cancer patients. In contrast to the results of a published study, the present study shows that B7-H4 rs3738414 polymorphism GG genotype was found in higher … |
| Anahtar Kelimeler |
| B7-H4 | Breast cancer | FGFR2 | polymorphism |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 10 |
| Scopus | 12 |