Association of B7-H4 gene polymorphisms in urothelial bladder cancer
Yazarlar (8)
Doç. Dr. Asuman ÖZGÖZ Kastamonu Üniversitesi, Türkiye
M.Murat Şamlı
Acıbadem Mehmet Ali Aydınlar Üniversitesi, Türkiye
Acıbadem Mehmet Ali Aydınlar Üniversitesi, Türkiye
Doç. Dr. Deniz Dinçel Uludağ Üniversitesi, Türkiye
Prof. Dr. Ahmet Şahin Acıbadem Mehmet Ali Aydınlar Üniversitesi, Türkiye
Prof. Dr. Ümit İnce Acıbadem Mehmet Ali Aydınlar Üniversitesi, Türkiye
Doç. Dr. Yeşim Sağlıcan Acıbadem Mehmet Ali Aydınlar Üniversitesi, Türkiye
Faruk Balcı
Uludağ Üniversitesi, Türkiye
Uludağ Üniversitesi, Türkiye
Prof. Dr. Hale Şamlı Uludağ Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Turkish Journal of Medical Sciences (Q4) | ||
| Dergi ISSN | 1300-0144 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2017 |
| Cilt / Sayı / Sayfa | 47 / 2 / 443–446 | DOI | 10.3906/sag-1603-54 |
| Makale Linki | https://doi.org/10.3906/sag-1603-54 | ||
| UAK Araştırma Alanları |
Tıbbi Genetik
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| Özet |
| Background/aim: We aimed to study polymorphisms of the B7-H4 gene in order to evaluate a possible association in urothelial carcinoma, as it is highly expressed in cancer tissues. Materials and methods: In this study B7-H4 gene rs10754339, rs10801935, and rs3738414 SNPs were studied by PCR-RFLP method in paraffin-embedded tumor specimens from 62 urothelial carcinoma patients and in a control group including 30 patients without bladder cancer. Results: We detected that the rs10754339 polymorphism was more frequent in the cancer patients when compared with the control group (P < 0.05). Only the rs3738414 polymorphism showed a statistically significant difference in frequency between pathologic diagnostic groups. Conclusion: The rs10754339 AA genotype distribution was found to have a higher frequency whereas the rs3738414 AG genotype distribution was lower in the bladder cancer group (P < 0.05). None of the genotype distributions showed a significant difference from the control group for the rs10801935 polymorphism. We conclude that B7-H4 has the potential to be a useful prognostic marker in urothelial carcinoma. |
| Anahtar Kelimeler |
| B7-H4 gene | Bladder cancer | Polymorphism |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 4 |