| Yazarlar |
Doç. Dr. Asuman ÖZGÖZ
Kastamonu Üniversitesi, Türkiye |
M.Murat Şamlı
Acıbadem Mehmet Ali Aydınlar Üniversitesi, Türkiye |
|
Deniz Dinçel
Uludağ Üniversitesi, Türkiye |
|
Ahmet Şahin
Acıbadem Mehmet Ali Aydınlar Üniversitesi, Türkiye |
|
Ümit İnce
Acıbadem Mehmet Ali Aydınlar Üniversitesi, Türkiye |
|
Yeşim Sağlıcan
Acıbadem Mehmet Ali Aydınlar Üniversitesi, Türkiye |
|
Faruk Balcı
Uludağ Üniversitesi, Türkiye |
|
Hale Şamlı
Uludağ Üniversitesi, Türkiye |
| Özet |
| Background/aim: We aimed to study polymorphisms of the B7-H4 gene in order to evaluate a possible association in urothelial carcinoma, as it is highly expressed in cancer tissues. Materials and methods: In this study B7-H4 gene rs10754339, rs10801935, and rs3738414 SNPs were studied by PCR-RFLP method in paraffin-embedded tumor specimens from 62 urothelial carcinoma patients and in a control group including 30 patients without bladder cancer. Results: We detected that the rs10754339 polymorphism was more frequent in the cancer patients when compared with the control group (P < 0.05). Only the rs3738414 polymorphism showed a statistically significant difference in frequency between pathologic diagnostic groups. Conclusion: The rs10754339 AA genotype distribution was found to have a higher frequency whereas the rs3738414 AG genotype distribution was lower in the bladder cancer group (P < 0.05). None of the genotype distributions showed a significant difference from the control group for the rs10801935 polymorphism. We conclude that B7-H4 has the potential to be a useful prognostic marker in urothelial carcinoma. |
| Anahtar Kelimeler |
| B7-H4 gene | Bladder cancer | Polymorphism |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | TURKISH JOURNAL OF MEDICAL SCIENCES |
| Dergi ISSN | 1300-0144 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2017 |
| Cilt No | 47 |
| Sayı | 2 |
| Sayfalar | 443 / 446 |
| Doi Numarası | 10.3906/sag-1603-54 |
| Atıf Sayıları | |
| SCOPUS | 4 |
| TRDizin | 1 |
