Vascular endothelial growth factor gene 1154 G A 2578 C A 460 C T 936 C T polymorphisms and association with recurrent pregnancy losses
Yazarlar (5)
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
|
||
| Dergi Adı | Genetics and Molecular Research Gmr (Q4) | ||
| Dergi ISSN | 1676-5680 Dergi Bilgileri (2012) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2012 |
| Cilt / Sayı / Sayfa | 11 / 4 / 4739–4745 | DOI | 10.4238/2012.December.17.6 |
| Makale Linki | https://www.geneticsmr.com/articles/1991 | ||
| UAK Araştırma Alanları |
Tıbbi Genetik
|
||
| Özet |
| Vascular endothelial growth factor (VEGF) regulates endothelial cell proliferation, migration and differentiation. VEGF plays a critical role in angiogenesis during placenta formation. We investigated whether VEGF gene polymorphisms are associated with recurrent pregnancy loss. Thirty-eight women with recurrent pregnancy loss and 30 control women with live-born children were recruited from 2010 to 2011 in the region of Bursa, Turkey. VEGF gene polymorphisms were assessed with PCR-RFLP analysis of DNA samples obtained from leukocytes. DNA fragments were investigated by using appropriate primers. SNP scanning was performed using MnII, BgIII, BshI2361, Hsp92II restriction enzymes for 1154 G/A, 2578 C/A, 460 C/T, and 936 C/T polymorphisms, respectively. The frequencies of 2578 C/A, 460 C/T, 936 C/T polymorphisms were not significantly different between the controls and women with recurrent pregnancy loss. However, the |
| Anahtar Kelimeler |
| Polymorphisms | Recurrent pregnancy loss | VEGF |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 21 |
| Scopus | 27 |