Visfatin polymorphism may increase tendency to diabetic nephropathy
Yazarlar (6)
Prof. Dr. Serap Demir Mersin Üniversitesi, Türkiye
Doç. Dr. Asuman ÖZGÖZ Kastamonu Üniversitesi, Türkiye
Doç. Dr. Fadime Mutlu İçduygu Giresun Üniversitesi, Türkiye
Doç. Dr. Kuyaş Hekimler Öztürk Süleyman Demirel Üniversitesi, Türkiye
Prof. Dr. Tülay Köken Afyonkarahisar Sağlık Bilimleri Üniversitesi, Türkiye
Necat İmirzalıoğlu Girne Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(Uluslararası alan indekslerindeki dergilerde yayınlanan tam makale)
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| Dergi Adı | Nephrology Reviews | ||
| Dergi ISSN | 2035-813X | ||
| Dergi Tarandığı Indeksler | EBSCOHOST | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2012 |
| Cilt / Sayı / Sayfa | 4 / 1 / – | DOI | 10.4081/nr.2012.e4 |
| Makale Linki | https://doi.org/10.4081/nr.2012.e4 | ||
| UAK Araştırma Alanları |
Tıbbi Genetik
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| Özet |
| Visfatin is a novel adipocytokine, which is suggested to play a role in kidney diseases. We hypothesized that diabetics with diabetic nephropathy may have a different gene profile and this study was performed to evaluate the association between visfatin gene promoter region SNPs and diabetic nephropathy. Realtime PCR was used to study SNPs (1001T/G, 423A/G, 1535C/T) of the visfatin gene promoter region in 30 type 2 diabetics with nephropathy, 30 type 2 diabetics without nephropathy, and 30 healthy volunteers who served as control. Routine biochemical parameters, serum insulin, TNF-α, urinary protein and microalbumine were tested in subjects. Insulin resistance was evaluated by the HOMA method. Non-heterozygotes for the SNPs 423 A/G and 1001 T/G had significantly less risk of having nephropathy (for each group odds ratio 0.181 with 95% confidence interval:0.048–0.674). They also had lower … |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |