Thio/carbohydrazone derivatives from iso(thio)/cyanates: preparation, structure elucidation, DFT studies, antimicrobial activity and DNA interactions
Yazarlar (5)
Prof. Dr. Muhammet Serdar ÇAVUŞ Kastamonu Üniversitesi, Türkiye
Doç. Dr. Hasan Yakan Ondokuz Mayıs Üniversitesi, Türkiye
Dr. Öğr. Üyesi Ceren Başkan Amasya Üniversitesi, Türkiye
Musa Erdoğan Kafkas Üniversitesi, Türkiye
Prof. Dr. Halit MUĞLU Kastamonu Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Research on Chemical Intermediates (Q2) | ||
| Dergi ISSN | 0922-6168 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 04-2023 |
| Kabul Tarihi | 04-04-2023 | Yayınlanma Tarihi | 22-04-2023 |
| Cilt / Sayı / Sayfa | 49 / 6 / 2639–2667 | DOI | 10.1007/s11164-023-05014-6 |
| Makale Linki | http://dx.doi.org/10.1007/s11164-023-05014-6 | ||
| UAK Araştırma Alanları |
Atom, Molekül ve Lazer Fiziği
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| Özet |
| New thio/carbohydrazone derivatives (1–10) have been synthesized from various iso(thio)/cyanates. The chemical structures of synthesized compounds were elucidated with UV–Vis, IR, 1H NMR, 13C NMR spectroscopic methods, and elemental analysis. Antimicrobial activities of all synthesized compounds against Gram-positive, Gram-negative mold and yeast were screened by disc diffusion and microdilution methods. Ground state structures were obtained with the DFT approach, and also, experimental data were supported by spectroscopy calculations. In addition to calculating the reactivity parameters, intramolecular interactions and electron density distributions were analyzed and approaches to the antimicrobial properties of the compounds were presented. Furthermore, the interaction between the compounds and pBR322 plasmid DNA was investigated by gel electrophoresis. In this study to investigate the … |
| Anahtar Kelimeler |
| Antimicrobial activity | DFT | DNA interactions | Spectroscopic studies | Thio/carbohydrazones |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 6 |
| Scopus | 7 |
| Google Scholar | 7 |