A new series of asymmetric bis-isatin derivatives containing urea/thiourea moiety: Preparation, spectroscopic elucidation, antioxidant properties and theoretical calculations
Yazarlar (6)
Doç. Dr. Hasan Yakan Ondokuz Mayıs Üniversitesi, Türkiye
Prof. Dr. Muhammet Serdar ÇAVUŞ Kastamonu Üniversitesi, Türkiye
Prof. Dr. Belma Zengin Kurt Bezmiâlem Vakıf Üniversitesi, Türkiye
Prof. Dr. Halit MUĞLU Kastamonu Üniversitesi, Türkiye
Prof. Dr. Fatih Sönmez Sakarya University Of Applied Sciences, Türkiye
Prof. Dr. Emre Güzel Sakarya Uygulamalı Bilimler Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Molecular Structure (Q3) | ||
| Dergi ISSN | 0022-2860 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 09-2021 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-09-2021 |
| Cilt / Sayı / Sayfa | 1239 / 1 / 130495–0 | DOI | 10.1016/j.molstruc.2021.130495 |
| Makale Linki | http://dx.doi.org/10.1016/j.molstruc.2021.130495 | ||
| UAK Araştırma Alanları |
Atom, Molekül ve Lazer Fiziği
|
||
| Özet |
| In the present study, design, synthesis, characterization, and investigation of antioxidant properties of novel asymmetric bis-isatin derivatives (1-8) containing urea/thiourea moiety are reported for the first time. FT-IR, 1H-NMR, and 13C-NMR spectroscopic methods and elemental analysis were used to elucidate the structures of the synthesized compounds. Their CUPRAC and ABTS cation radical scavenging abilities were investigated for antioxidant activity. The bis-isatins containing urea moiety (compounds 1-4) did not show ABTS activity, while those containing the thiourea moiety (compounds 5-8) showed moderate ABTS activity. Besides, all bis-isatins were observed to exhibit CUPRAC activity at a low micromolar level The 1-(5-chloro-2-oxoindolin-3-ylidene)-5-(2-oxoindolin-3-ylidene)thiocarbonohydrazide (compound 5) showed the highest ABTS activity with IC50 value of 18.44 µM; on the other hand, the 1-(5 … |
| Anahtar Kelimeler |
| antioxidant evaluation | Asymmetric bis-isatin | DFT | Intrinsic bond strength index (IBSI) | Laplacian bond order (LBO) | structure characterization |
Science Direct
A new series of asymmetric bis-isatin derivatives containing urea/thiourea moiety: Preparation, spectroscopic elucidation, antioxidant properties and theoretical calculations
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 26 |
| Scopus | 28 |
| Google Scholar | 37 |