| Yazarlar (14) |
Tony Charman
King's College London, İngiltere |
|
Greg Pasco
King's College London, İngiltere |
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Alexandra Hendry
University Of Oxford Medical Sciences Division, İngiltere |
|
Tessel Bazelmans
King's College London, İngiltere |
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Nisha Narvekar
King's College London, İngiltere |
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Amy Goodwin
King's College London, İngiltere |
|
Hanna Halkola
King's College London, İngiltere |
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Mary Agyapong
King's College London, İngiltere |
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Rebecca Holman
Birkbeck, University Of London, İngiltere |
|
Ali Jannath Begum
|
Dr. Öğr. Üyesi Mutluhan ERSOY
Kastamonu Üniversitesi, Türkiye |
|
Mark H Johnson
Birkbeck, University Of London, İngiltere |
|
Andrew Pickles
King's College London, İngiltere |
|
Emily J Jones
Birkbeck, University Of London, İngiltere |
| Özet |
| Background: Most research on early outcomes in infants with a family history (FH) of autism has focussed on categorically defined autism, although some have language and developmental delays. Less is known about outcomes in infants with a FH of attention deficit hyperactivity disorder (ADHD). Methods: Infants with and without a FH of autism and/or ADHD, due to a first-degree relative with either or both conditions, were recruited at 5 or 10 months. Three year outcomes were characterised using latent profile analysis (LPA) across measures of cognitive ability, adaptive functioning and autism, ADHD and anxiety traits (n = 131). We additionally ran an LPA using only autism and ADHD measures, and the broader LPA in an independent cohort (n = 139) and in both cohorts combined (n = 270). Results: A Low Developmental Level + High Behavioural Concerns class had elevated autism, ADHD and anxiety scores, low cognitive and adaptive function, and included all but one child with autism. A Low Developmental Level + Typical Behaviour class had average cognitive ability and typical behaviour but low adaptive function. A Typical Developmental Level + Some Behavioural Concerns class had average cognitive and adaptive function but slightly elevated behaviour scores. A High Developmental Level + Typical Behaviour class had above average cognitive ability and typical behaviour. All four LPAs identified classes characterised by combinations of either, or both, Low Development Level and elevated behaviour scores, as well as a typically developing class. No classes had elevated autism or ADHD traits in isolation. Conclusions: Some infants with a FH of autism or ADHD have atypical developmental and behavioural outcomes, but do not show strong autism or ADHD traits in isolation. The field needs to recalibrate aims and methods to embrace the broader transdiagnostic pattern of outcomes seen in these infants. |
| Anahtar Kelimeler |
| ADHD | autism | early childhood | infancy | latent profile analysis |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | ESCI dergilerinde yayınlanan tam makale |
| Dergi Adı | JCPP ADVANCES |
| Dergi ISSN | 2692-9384 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | DOAJ |
| Makale Dili | İngilizce |
| Basım Tarihi | 12-2023 |
| Cilt No | 3 |
| Sayı | 4 |
| Doi Numarası | 10.1002/jcv2.12189 |
| Atıf Sayıları | |
| WoS | 8 |
| SCOPUS | 9 |
| Google Scholar | 9 |
