Three year outcomes in infants with a family history of autism and/or attention deficit hyperactivity disorder

Charman, Tony; Pasco, Greg; ERSOY, Mutluhan; Johnson, Mark H.; Pickles, Andrew; Jones, Emily J.H.; Hendry, Alexandra; Bazelmans, Tessel; Narvekar, Nisha; Goodwin, Amy; Halkola, Hanna; Agyapong, Mary; Holman, Rebecca; Ali, Jannath Begum

doi:10.1002/jcv2.12189

Three year outcomes in infants with a family history of autism and/or attention deficit hyperactivity disorder

Yazarlar (14)

Tony Charman King's College London, İngiltere

Greg Pasco King's College London, İngiltere

Alexandra Hendry
University Of Oxford Medical Sciences Division, İngiltere

Tessel Bazelmans King's College London, İngiltere

Nisha Narvekar King's College London, İngiltere

Amy Goodwin King's College London, İngiltere

Hanna Halkola King's College London, İngiltere

Mary Agyapong King's College London, İngiltere

Rebecca Holman
Birkbeck, University Of London, İngiltere

Jannath Begum Ali
Birkbeck, University Of London, İngiltere

Dr. Öğr. Üyesi Mutluhan ERSOY Kastamonu Üniversitesi, Türkiye

Mark H. Johnson
Birkbeck, University Of London, İngiltere

Andrew Pickles King's College London, İngiltere

Emily J.H. Jones
Birkbeck, University Of London, İngiltere

Makale Türü	Özgün Makale (ESCI dergilerinde yayınlanan tam makale)
Dergi Adı	Jcpp Advances
Dergi ISSN	2692-9384 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler	DOAJ
Makale Dili	İngilizce	Basım Tarihi	08-2023
Kabul Tarihi	–	Yayınlanma Tarihi	02-08-2023
Cilt / Sayı / Sayfa	3 / 4 / –	DOI	10.1002/jcv2.12189
Makale Linki	https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jcv2.12189
UAK Araştırma Alanları	Çocuk/Ergen Psikopatolojisi

Özet

AbstractBackgroundMost research on early outcomes in infants with a family history (FH) of autism has focussed on categorically defined autism, although some have language and developmental delays. Less is known about outcomes in infants with a FH of attention deficit hyperactivity disorder (ADHD).MethodsInfants with and without a FH of autism and/or ADHD, due to a first‐degree relative with either or both conditions, were recruited at 5 or 10 months. Three year outcomes were characterised using latent profile analysis (LPA) across measures of cognitive ability, adaptive functioning and autism, ADHD and anxiety traits (n = 131). We additionally ran an LPA using only autism and ADHD measures, and the broader LPA in an independent cohort (n = 139) and in both cohorts combined (n = 270).ResultsA Low Developmental Level + High Behavioural Concerns class had elevated autism, ADHD and anxiety scores, low cognitive and adaptive function, and included all but one child with autism. A Low Developmental Level + Typical Behaviour class had average cognitive ability and typical behaviour but low adaptive function. A Typical Developmental Level + Some Behavioural Concerns class had average cognitive and adaptive function but slightly elevated behaviour scores. A High Developmental Level + Typical Behaviour class had above average cognitive ability and typical behaviour. All four LPAs identified classes characterised by combinations of either, or both, Low Development Level and elevated behaviour scores, as well as a typically developing class. No classes had elevated autism or ADHD traits in isolation.ConclusionsSome infants with a FH of autism or ADHD have atypical developmental and behavioural outcomes, but do not show strong autism or ADHD traits in isolation. The field needs to recalibrate aims and methods to embrace the broader transdiagnostic pattern of outcomes seen in these infants.

Anahtar Kelimeler

ADHD | autism | early childhood | infancy | latent profile analysis

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BM Sürdürülebilir Kalkınma Amaçları

Atıf Sayıları
Web of Science	10
Scopus	10
Google Scholar	11

Three year outcomes in infants with a family history of autism and/or attention deficit hyperactivity disorder

Dergi Adı	JCPP Advances
Yayıncı	John Wiley and Sons Ltd
Açık Erişim	Evet
ISSN	2692-9384
E-ISSN	2692-9384
CiteScore	6,0
SJR	1,400
SNIP	1,125

Three year outcomes in infants with a family history of autism and/or attention deficit hyperactivity disorder

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