Presence of quorum sensing system, virulence genes, biofilm formation and relationship among them and class 1 integron in carbapenem-resistant clinical Pseudomonas aeruginosa isolates
Yazarlar (6)
Dr. Öğr. Üyesi Ceren Başkan Amasya Üniversitesi, Türkiye
Prof. Dr. Belgin Sırıken Ondokuz Mayis Üniversitesi, Türkiye
Dr. Öğr. Üyesi Enis Fuat TÜFEKCİ Kastamonu Üniversitesi, Türkiye
Çetin Kılınç
Kastamonu Üniversitesi, Türkiye
Kastamonu Üniversitesi, Türkiye
Prof. Dr. Ömer Ertürk Ordu Üniversitesi, Türkiye
İrfan Erol
Eastern Mediterranean University, Kıbrıs Rum Kesimi
Eastern Mediterranean University, Kıbrıs Rum Kesimi
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Archives of Microbiology (Q3) | ||
| Dergi ISSN | 0302-8933 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2022 |
| Cilt / Sayı / Sayfa | 204 / 8 / – | DOI | 10.1007/s00203-022-03061-y |
| Makale Linki | http://dx.doi.org/10.1007/s00203-022-03061-y | ||
| UAK Araştırma Alanları |
Tıbbi Mikrobiyoloji
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| Özet |
| Carbapenems are the most effective agents for treating clinical P. aeruginosa (PsA) infections. During an infection, a quorum-sensing (QS) system and its regulating virulence genes have a great role. The aim of the study was to detect the presence of a las and rhl QS system and related virulence genes, biofilm formation and a class 1 (Cls1) integron. A total of 52 carbapenem-resistant PsA (CRPsA) isolates obtained from Kastamonu, Turkey was analyzed. For the isolation and identification of CRPsA isolates, a conventional culture method, an automated VITEK-2 compact system, and oprL gene-based molecular technique were applied. The two QS system genes were detected in 51 (98.1%), and co-existed of four two QS system genes (lasI/R and rhIl/R genes) were determined in 41 (78.8%) of the isolates. algD, lasB, toxA and aprA genes were detected in between 46.1 and 88.5%, and co-existence of four two QS … |
| Anahtar Kelimeler |
| Biofilm | Carbapenem-resistant Pseudomonas aeruginosa | Class 1 integron | QS system | Virulence genes |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 7 |
| Google Scholar | 14 |