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Anticancer and biological properties of leaf and flower extracts of Echinacea purpurea (L.) Moench     
Yazarlar
Khawla Omran Mohamed Sharıf
Dr. Öğr. Üyesi Enis Fuat TÜFEKCİ
Kastamonu Üniversitesi, Türkiye
Buket Ustaoğlu
Prof. Dr. Yasemin ÇELİK ALTUNOĞLU
Kastamonu Üniversitesi, Türkiye
Gökhan Zengin
Selçuk Üniversitesi, Türkiye
Llorent-Martinez E.J.
Dr. Öğr. Üyesi Kerim GÜNEY
Türkiye
Prof. Dr. Mehmet Cengiz BALOĞLU
Kastamonu Üniversitesi, Türkiye
Özet
Echinacea purpurea (L.) Moench is an important medicinal herb; its roots, leaves and, flowers have been used by the food and pharmaceutical industries. In this study, DNA protection, antimicrobial, antioxidant-enzyme inhibition, and antiproliferative activities of water, methanol (MeOH), and ethyl acetate (EA) extracts of leaves and flowers of E. purpurea were evaluated. In addition, total phenolics and flavonoids, as well as individual compounds, were identified using colorimetric assays and HPLC-ion trap mass spectrometry, respectively. Chicoric acid and its isomer were the most abundant natural compounds, with concentrations similar to previous studies of E. purpurea. All extracts had antimicrobial activity against a broad range of bacteria, particularly Enterococcus faecalis. The antiproliferative activity of the extracts on the HeLa cells was shown. The lowest value of IC50 (73 μg/ml) came from the 24 h MeOH extract of flowers. The water extract of leaves showed strong antioxidant activity with the DPPH, ABTS, CUPRAC, and FRAP assays. EA and MeOH extracts of leaves showed a significant inhibition ability of cholinesterase and tyrosinase, respectively. The presented study suggested that E. purpurea extracts had promising therapeutic properties. Further investigation at the cellular level could be done to highlight the mechanism behind these biological activities.
Anahtar Kelimeler
American coneflower | Chicoric acid | Echinacea purpurea (L.) Moench | HeLa cells | Medicinal herbs
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı Food Bioscience
Dergi ISSN 2212-4292
Dergi Tarandığı Indeksler SCI-Expanded
Dergi Grubu Q2
Makale Dili İngilizce
Basım Tarihi 03-2021
Cilt No 41
Sayı 1
Doi Numarası 10.1016/j.fbio.2021.101005
Makale Linki http://dx.doi.org/10.1016/j.fbio.2021.101005