| Yazarlar |
Abdulkadir Yıldırım
Atatürk Üniversitesi, Türkiye |
|
Konca Kızılkaynak
|
|
Hülya Aksoy
Atatürk Üniversitesi, Türkiye |
Prof. Dr. Yaşar Nuri ŞAHİN
Atatürk Üniversitesi, Türkiye |
|
Fatih Akçay
Atatürk Üniversitesi, Türkiye |
| Özet |
| The aim of the present study was to measure plasma uric acid (UA) levels and superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and xanthine oxidase (XO) activities and to evaluate the relationship between these parameters and the severity of pre-eclampsia. Twenty-five pre-eclamptic, 15 healthy pregnant and 15 non-pregnant women were enrolled in this study. Increased mean plasma XO activity was found to be higher in both pre-eclampsia groups than in the healthy pregnant group. Plasma UA levels were the highest in the severe pre-eclampsia group among the study groups. SOD and GSH-Px activities were significantly lower in both pre-eclampsia groups than in the healthy pregnant group (p < 0.005 andp < 0.001, respectively). Increased XO and decreased SOD and GSH-Px activities may contribute to the pathophysiological mechanisms of pre-eclampsia and increased UA may serve a protective role responding to superoxide radicals arising from increased XO activity or other sources in pre-eclampsia. Copyright © 2004 John Wiley & Sons, Ltd. |
| Anahtar Kelimeler |
| Glutathione peroxidase | Pre-eclampsia | Superoxide dismutase | Xanthine oxidase |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Cell Biochemistry and Function |
| Dergi ISSN | 0263-6484 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 07-2004 |
| Cilt No | 22 |
| Sayı | 4 |
| Sayfalar | 213 / 217 |
| Doi Numarası | 10.1002/cbf.1090 |
| Makale Linki | http://doi.wiley.com/10.1002/cbf.1090 |
| Atıf Sayıları | |
| SCOPUS | 26 |
| Google Scholar | 51 |
