Plasma xanthine oxidase superoxide dismutase and glutathione peroxidase activities and uric acid levels in severe and mild pre eclampsia
Yazarlar (5)
Öğr. Gör. Abdulkadir Yıldırım Atatürk Üniversitesi, Türkiye
Konca Kızılkaynak
Hülya Aksoy Atatürk Üniversitesi, Türkiye
Yaşar Nuri Şahin
Atatürk Üniversitesi, Türkiye
Atatürk Üniversitesi, Türkiye
Doç. Dr. Fatih Akçay Atatürk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Cell Biochemistry and Function | ||
| Dergi ISSN | 0263-6484 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2004 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 04-02-2004 |
| Cilt / Sayı / Sayfa | 22 / 4 / 213–217 | DOI | 10.1002/cbf.1090 |
| Makale Linki | http://doi.wiley.com/10.1002/cbf.1090 | ||
| UAK Araştırma Alanları |
Tıbbi Biyokimya
|
||
| Özet |
| The aim of the present study was to measure plasma uric acid (UA) levels and superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and xanthine oxidase (XO) activities and to evaluate the relationship between these parameters and the severity of pre-eclampsia. Twenty-five pre-eclamptic, 15 healthy pregnant and 15 non-pregnant women were enrolled in this study. Increased mean plasma XO activity was found to be higher in both pre-eclampsia groups than in the healthy pregnant group. Plasma UA levels were the highest in the severe pre-eclampsia group among the study groups. SOD and GSH-Px activities were significantly lower in both pre-eclampsia groups than in the healthy pregnant group (p < 0.005 andp < 0.001, respectively). Increased XO and decreased SOD and GSH-Px activities may contribute to the pathophysiological mechanisms of pre-eclampsia and increased UA may serve a protective role responding to superoxide radicals arising from increased XO activity or other sources in pre-eclampsia. Copyright © 2004 John Wiley & Sons, Ltd. |
| Anahtar Kelimeler |
| Glutathione peroxidase | Pre-eclampsia | Superoxide dismutase | Xanthine oxidase |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |