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Prognostic value of neutrophile-to-lymphocyte ratio (NLR) and lactate dehydrogenase (LDH) levels for geriatric patients with COVID-19    
Yazarlar
Uğur Önal
Türkiye
Muhammet Gülhan
Türkiye
Neşe Demirci
Ahmet Özden
Türkiye
Dr. Öğr. Üyesi Nazlı EROL
Türkiye
Sema Işık
Türkiye
Doç. Dr. Sedat GÜLTEN
Kastamonu Üniversitesi, Türkiye
Dr. Öğr. Üyesi Fatma ATALAY
Kastamonu Üniversitesi, Türkiye
Nilay Çöplü
Türkiye
Özet
In this study it was aimed to evaluate the prognostic factors for the geriatric patients with confirmed COVID-19 in a tertiary-care hospital at Kastamonu region of Turkey. Patients (≥65-year-old) who had PCR positivity for COVID-19 between March 2020 and April 2020 in our center were recorded retrospectively. A p value less than 0.05 was considered significant. Ethical committee approval was given from the Bolu University with decision number 2020/176. There were a total of 100 patients (44% female). In-hospital mortality was recorded as 7%. In univariate analysis for 1 month mortality, diabetes mellitus (p = 0.038), leucocyte count (p = 0.005), neutrophile count (p = 0.02), neutrophile-to-lymphocyte ratio (NLR) (p < 0.001), thrombocyte-to-lymphocyte ratio (TLR) (p = 0.001), C-reactive protein (CRP) (p = 0.002), lactate dehydrogenase (LDH) (p = 0.001), sequential organ failure assessment (SOFA) score (p = 0.001) and qSOFA score (p = 0.002) were found as independent risk factors. On admission, one point increase of NLR (p = 0.014, odds ratio (OR) = 1.371, 95% CI = 1.067-1.761) and one point increase of LDH (p = 0.047, OR = 1.011, 95% CI = 1.001-1.023) were associated with mortality on day 30 according to logistic regression analysis. The cut-off values were found as > 7.8 for NLR (83.33% sensitivity, 97.7% specificity) and > 300 U/L for LDH (100% sensitivity, 79.31% specificity) regarding the prediction of 30-day mortality. In order to improve clinical management and identify the geriatric patients with COVID-19 who have high risk for mortality, NLR and LDH levels on admission might be useful prognostic tools.
Anahtar Kelimeler
Covid-19 | Geriatric patients | Neutrophile-to-lymphocyte ratio, lactate dehydrogenase | Prognostic factors
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı BMC GERIATRICS
Dergi ISSN 1471-2318
Dergi Tarandığı Indeksler SCI-Expanded
Dergi Grubu Q3
Makale Dili İngilizce
Basım Tarihi 04-2022
Cilt No 22
Sayı 1
Sayfalar 1 / 6
Doi Numarası 10.1186/s12877-022-03059-7
Makale Linki http://dx.doi.org/10.1186/s12877-022-03059-7