Amitriptilinin Çipura (Sparus aurata) Serum Biyokimyası Üzerindeki Etkisi
Yazarlar (4)
Arş. Gör. Dr. Osman Nezih KENANOĞLU Kastamonu Üniversitesi, Türkiye
Arş. Gör. Nihan Akıncı Kenanoğlu Türkiye
Prof. Dr. Sevdan Yılmaz Türkiye
Doç. Dr. Soner BİLEN Kastamonu Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(Diğer hakemli uluslarası dergilerde yayınlanan tam makale)
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| Dergi Adı | Environmental Toxicology and Ecology | ||
| Dergi ISSN | 2757-9719 | ||
| Makale Dili | İngilizce | Basım Tarihi | 04-2022 |
| Cilt / Sayı / Sayfa | 2 / 1 / 66–75 | DOI | – |
| Makale Linki | https://dergipark.org.tr/en/download/article-file/2342041 | ||
| UAK Araştırma Alanları |
Temel Bilimler
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| Özet |
| Amitriptyline is a tricyclic antidepressant that is frequently used in the treatment of many neuropathic and inflammatory diseases as well as depression. As a result of contamination to the aquatic environment, the effects of amitriptyline antidepressant, which has long lasting properties, on the serum biochemistry of gilthead sea bream fish was investigated in this study. For this purpose, gilthead sea bream were exposed to amitriptyline concentrations of 0.2 µg/L, 10 µg/L, 100 µg/L and 1000 µg/L for 14 days. Glucose, albumin, globulin, total protein, triglyceride, cholesterol, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and lactate dehydrogenase biochemical parameters were determined from the blood serum samples of the fish taken on the 7th and 14th days of the study. Significant changes occurred on the 14th day in the values of triglyceride, cholesterol, aspartate aminotransferase, alkaline phosphatase and lactate dehydrogenase, which did not show a significant difference on the 7th day. These results reveal that different amitriptyline concentrations cause negative changes in the fish biochemistry. |
| Anahtar Kelimeler |
