Inflammatory Responses in the Japanese Pufferfish Takifugu rubripes Head Kidney Cells Stimulated with an Inflammasome Inducing Agent Nigericin
Yazarlar (6)
Doç. Dr. Soner BİLEN Kastamonu Üniversitesi, Türkiye
Gouranga Biswas
University Of Miyazaki, Japonya
University Of Miyazaki, Japonya
Shohei Otsuyama
University Of Miyazaki, Japonya
University Of Miyazaki, Japonya
Tomoya Kono
University Of Miyazaki, Japonya
University Of Miyazaki, Japonya
Masahiro Sakai
University Of Miyazaki, Japonya
University Of Miyazaki, Japonya
Jun İchi Hikima
University Of Miyazaki, Japonya
University Of Miyazaki, Japonya
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Developmental and Comparative Immunology (Q1) | ||
| Dergi ISSN | 0145-305X Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 10-2014 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-10-2014 |
| Cilt / Sayı / Sayfa | 46 / 2 / 222–230 | DOI | 10.1016/j.dci.2014.04.010 |
| Makale Linki | https://www.sciencedirect.com/science/article/pii/S0145305X14001062?casa_token=zedlm_tULJ0AAAAA:RP1LHRWcB3IbPBk8mvIRB9sbuyBOeN1QnupUJvS6tKV14cTRinBNQkVdPVRkBGqB4Ka49_E7-8g | ||
| UAK Araştırma Alanları |
Su Ürünleri Yetiştiriciliği
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| Özet |
| A cytosolic receptor complex called inflammasome is responsible for mounting inflammatory response by releasing pro-inflammatory cytokines, interleukin (IL)-1β and IL-18. However, inflammatory cascades mediated by the inflammasome are unknown in a lower vertebrate like fish. Therefore, in an in vitro experiment, in order to obtain a preliminary information, we conducted transcriptomic analysis of 18 cytokines including pro-inflammatory cytokines in the Japanese pufferfish (Takifugu rubripes) head kidney (HK) cells stimulated with an inflammasome-inducing agent, nigericin, and a combination of nigericin and LPS by a multiplex RT-PCR assay (GenomeLab Genetic Analysis System, GeXPS; Beckman Coulter Inc.). Furthermore, expression of IL-1β, IL-6, IL-18, nuclear factor (NF)-κB, nucleotide-binding oligomerization domain 2 (NOD2) and NOD-like receptor X1 (NLRX1) genes was examined in HK cells by a … |
| Anahtar Kelimeler |
| Japanese pufferfish | Multiplex RT-PCR assay | Nigericin | Pro-inflammatory cytokines |
Science Direct
Inflammatory Responses in the Japanese Pufferfish Takifugu rubripes Head Kidney Cells Stimulated with an Inflammasome Inducing Agent Nigericin
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| Atıf Sayıları | |
| Scopus | 31 |
| Google Scholar | 35 |