Drug Adherence in Patients With Nonvalvular Atrial Fibrillation Taking Non-Vitamin K Antagonist Oral Anticoagulants in Turkey: NOAC-TR
Yazarlar (20)
Sadık Volkan Emren Afyonkarahisar State Hospital, Türkiye
Oktay Şenöz Artvin State Hospital, Türkiye
Murat Bilgin Diskapi Education And Research Hospital, Türkiye
Osman Beton Cumhuriyet Üniversitesi, Türkiye
Abdullah Aslan Dokuz Eylül Üniversitesi, Türkiye
Uğur Taşkin Akşehir State Hospital, Türkiye
Gönül Açiksari Istinye State Hospital, Türkiye
Lale Dinç Asarcikli Diskapi Education And Research Hospital, Türkiye
Hakan Çakir Darıca Farabi State Hospital, Türkiye
Lütfü Bekar Hitit University, Türkiye
İsmail Bolat Fethiye State Hospital, Türkiye
Çağrı Yayla Ankara Yuksek Ihtisas Education And Research Hospital, Türkiye
Barış Çelebi
T. C. Sağlık Bakanlığı, Mersin Devlet Hastanesi, Türkiye
T. C. Sağlık Bakanlığı, Mersin Devlet Hastanesi, Türkiye
Onur Dalgiç Karsiyaka Devlet Hastanesi, Türkiye
Doç. Dr. Oğuzhan Çelik Hitit University, Türkiye
Özgen Şafak Burdur State Hospital, Türkiye
Serdar Akyel Dr. Munif Islamoglu Kastamonu State Hospital, Türkiye
Hasan Güngör School Of Medicine, Türkiye
Barış Düzel T. C. Sağlık Bakanlığı, Mersin Devlet Hastanesi, Türkiye
Mehdi Zoghi Ege Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS (Q4) | ||
| Dergi ISSN | 1076-0296 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 04-2018 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 19-02-2017 |
| Cilt / Sayı / Sayfa | 24 / 3 / 525–531 | DOI | 10.1177/1076029617693940 |
| Makale Linki | https://journals.sagepub.com/doi/pdf/10.1177/1076029617693940 | ||
| UAK Araştırma Alanları |
Kardiyoloji
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| Özet |
| Adherence to non-vitamin K antagonist oral anticoagulants (NOACs) is an important factor for ensuring efficacy and safety in nonvalvular atrial fibrillation (NVAF). There are controversial results regarding NOAC adherence in real-world data and there are no data about NOAC adherence in Turkish population. This study investigated the NOAC adherence based on self-report, factors affecting nonadherence, and the relation of the adherence level with efficacy and safety outcomes. This multicenter cross-sectional study included 2738 patients (59% female) using NOAC (dabigatran, apixaban, and rivaroxaban) due to NVAF for more than 3 months with >30 days of supply between September 1, 2015, and February 28, 2016. To measure the adherence level, an 8-item Morisky Medication Adherence Scale was used. The mean age of the patients was 70 ± 10 years. Of the 2738 patients, 44% were receiving dabigatran, 38% rivaroxaban, and 18% apixaban. A total of 630 (23%) patients had high medication adherence, 712 (26%) moderate adherence, and 1396 (51%) low adherence. Nonadherence had related to stroke (5.6% vs 2.5%, P <.001) and minor (21.2% vs 11.1%, P <.001) and major (6.1% vs 3.7%, P =.004) bleeding rates. The adherence to NOAC was found to be quite low in Turkey. Nonadherence is associated with bleeding and thromboembolic cardiovascular events. Age, taking NOAC twice a day, and the additional noncardiac diseases, depression, and dementia were the independent factors affecting poor medication adherence. |
| Anahtar Kelimeler |
| bleeding | medication adherence | non-vitamin K antagonists | self-report |
BM Sürdürülebilir Kalkınma Amaçları
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