| Yazarlar |
Sadık Volkan Emren
İzmir Katip Çelebi Üniversitesi, Türkiye |
|
Oktay Şenöz
|
|
Murat Bilgin
|
|
Osman Beton
Türkiye |
|
Abdullah Taha Aslan
Dokuz Eylül Üniversitesi, Türkiye |
|
Taşkin Uğur
|
|
Gönül Açıksarı
|
|
Lale Dinç Asarcıklı
|
|
Hakan Çakir
|
|
Lütfü Bekar
Hitit Üniversitesi, Türkiye |
|
İsmail Polat Canbolat
Demiroğlu Bilim Üniversitesi, Türkiye |
|
Çağrı Yayla
Sağlık Bilimleri Üniversitesi, Türkiye |
|
Barış Çelebi
|
|
Onur Dalgıç
|
|
Oğuzhan Çelik
|
|
Özgen Şafak
Balıkesir Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Serdar AKYEL
Kastamonu Üniversitesi, Türkiye |
|
Hasan Güngör
Aydın Adnan Menderes Üniversitesi, Türkiye |
|
Barış Düzel
|
|
Mehdi Zoghi
Ege Üniversitesi, Türkiye |
| Özet |
| Adherence to non-vitamin K antagonist oral anticoagulants (NOACs) is an important factor for ensuring efficacy and safety in nonvalvular atrial fibrillation (NVAF). There are controversial results regarding NOAC adherence in real-world data and there are no data about NOAC adherence in Turkish population. This study investigated the NOAC adherence based on self-report, factors affecting nonadherence, and the relation of the adherence level with efficacy and safety outcomes. This multicenter cross-sectional study included 2738 patients (59% female) using NOAC (dabigatran, apixaban, and rivaroxaban) due to NVAF for more than 3 months with >30 days of supply between September 1, 2015, and February 28, 2016. To measure the adherence level, an 8-item Morisky Medication Adherence Scale was used. The mean age of the patients was 70 ± 10 years. Of the 2738 patients, 44% were receiving dabigatran, 38% rivaroxaban, and 18% apixaban. A total of 630 (23%) patients had high medication adherence, 712 (26%) moderate adherence, and 1396 (51%) low adherence. Nonadherence had related to stroke (5.6% vs 2.5%, P <.001) and minor (21.2% vs 11.1%, P <.001) and major (6.1% vs 3.7%, P =.004) bleeding rates. The adherence to NOAC was found to be quite low in Turkey. Nonadherence is associated with bleeding and thromboembolic cardiovascular events. Age, taking NOAC twice a day, and the additional noncardiac diseases, depression, and dementia were the independent factors affecting poor medication adherence. |
| Anahtar Kelimeler |
| bleeding | medication adherence | non-vitamin K antagonists | self-report |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS |
| Dergi ISSN | 1076-0296 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 04-2018 |
| Cilt No | 24 |
| Sayı | 3 |
| Sayfalar | 525 / 531 |
| Doi Numarası | 10.1177/1076029617693940 |
| Makale Linki | http://journals.sagepub.com/doi/10.1177/1076029617693940 |
| Atıf Sayıları | |
| WoS | 34 |
| SCOPUS | 42 |
| Google Scholar | 66 |
