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The platelet-to-lymphocyte ratio as an inflammation marker in non-dipper hypertensive patients       
Yazarlar
Nergiz Bayrakçı
Nihal Aydemir
Hitit Üniversitesi, Türkiye
Fatma Akyel
Kastamonu Üniversitesi, Türkiye
Ihsan Ates
Dr. Öğr. Üyesi Serdar AKYEL
Kastamonu Üniversitesi, Türkiye
Fatih Dede
Sağlık Bilimleri Üniversitesi, Türkiye
Özet
Background: Non-dipper hypertensive patients have a higher risk of cardiovascular disease (CVD) than dipper hypertensive patients. Inflammation plays an important role in the pathogenesis and progression of CVD. This study aimed to determine the relationship between the platelet-to-lymphocyte ratio (PLR), and dipper and non-dipper hypertension. Materials and Methods: This prospective study included 199 consecutive patients that were diagnosed with primary hypertension. According to ambulatory blood pressure monitoring measurements, non-dipper and dipper group were determined. PLR was determined based on the platelet count and lymphocyte count in the complete blood count. Results: The non-dipper group included 103 patients (74 females and 29 males; mean age: 52.37 ± 10.7 years) and the dipper group included 96 patients (65 females and 31 males; mean age: 48.40 ± 11.1 years). Mean systolic blood pressure was significantly higher in the non-dipper group than in the dipper group (124 ± 15.1 mmHg versus 120 ± 11.2 mmHg, p =0.032) and the median PLR was significantly higher in the non-dipper group than in the dipper group [132.15 (range: 69.64-400) versus 117.0 (range: 53.52-192.26), p = 0.001], whereas the mean white blood cell count (6.86 ± 1.43 x 103/ µL versus 7.24 ± 1.26 x 103/VµL, p =0.046) and median lymphocyte count [2.09 (range: 0.95-3.92) x 107µL versus 2.24 (range: 0.97-3.98) x 10VµL, p =0.001) were significantly lower in the non-dipper group. Conclusion: Median PLR was significantly higher in the non-dipper hypertensive patients than in the dipper hypertensive patients. We think this finding further supports the role of an increase in inflammatory response in non-dipper hypertension.
Anahtar Kelimeler
Inflammation | Non-dipper hypertension | Platelet-to-lymphocyte ratio | PLR
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı HIPPOKRATIA
Dergi ISSN 1108-4189
Dergi Tarandığı Indeksler SCI-Expanded
Dergi Grubu Q4
Makale Dili İngilizce
Basım Tarihi 01-2015
Cilt No 19
Sayı 2
Sayfalar 114 / 118
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
WoS 16
SCOPUS 17
Google Scholar 34

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