| Yazarlar |
Nergiz Bayrakçı
|
|
Nihal Aydemir
Hitit Üniversitesi, Türkiye |
|
Fatma Akyel
Kastamonu Üniversitesi, Türkiye |
|
Ihsan Ates
|
Dr. Öğr. Üyesi Serdar AKYEL
Kastamonu Üniversitesi, Türkiye |
|
Fatih Dede
Sağlık Bilimleri Üniversitesi, Türkiye |
| Özet |
| Background: Non-dipper hypertensive patients have a higher risk of cardiovascular disease (CVD) than dipper hypertensive patients. Inflammation plays an important role in the pathogenesis and progression of CVD. This study aimed to determine the relationship between the platelet-to-lymphocyte ratio (PLR), and dipper and non-dipper hypertension. Materials and Methods: This prospective study included 199 consecutive patients that were diagnosed with primary hypertension. According to ambulatory blood pressure monitoring measurements, non-dipper and dipper group were determined. PLR was determined based on the platelet count and lymphocyte count in the complete blood count. Results: The non-dipper group included 103 patients (74 females and 29 males; mean age: 52.37 ± 10.7 years) and the dipper group included 96 patients (65 females and 31 males; mean age: 48.40 ± 11.1 years). Mean systolic blood pressure was significantly higher in the non-dipper group than in the dipper group (124 ± 15.1 mmHg versus 120 ± 11.2 mmHg, p =0.032) and the median PLR was significantly higher in the non-dipper group than in the dipper group [132.15 (range: 69.64-400) versus 117.0 (range: 53.52-192.26), p = 0.001], whereas the mean white blood cell count (6.86 ± 1.43 x 103/ µL versus 7.24 ± 1.26 x 103/VµL, p =0.046) and median lymphocyte count [2.09 (range: 0.95-3.92) x 107µL versus 2.24 (range: 0.97-3.98) x 10VµL, p =0.001) were significantly lower in the non-dipper group. Conclusion: Median PLR was significantly higher in the non-dipper hypertensive patients than in the dipper hypertensive patients. We think this finding further supports the role of an increase in inflammatory response in non-dipper hypertension. |
| Anahtar Kelimeler |
| Inflammation | Non-dipper hypertension | Platelet-to-lymphocyte ratio | PLR |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | HIPPOKRATIA |
| Dergi ISSN | 1108-4189 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2015 |
| Cilt No | 19 |
| Sayı | 2 |
| Sayfalar | 114 / 118 |
