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Akademisyenler > Gülsüm Ülke ÇALIŞKAN > Yayın Detayı

The Use of Macerated Garlic (Allium Sativum L.) Oil in Preventing the Postoperative Adhesions in Rats    
Yazarlar (2)
Doç. Dr. Gülsüm Ülke ÇALIŞKAN Doç. Dr. Gülsüm Ülke ÇALIŞKAN
Kastamonu Üniversitesi, Türkiye
Doç. Dr. Nuray EMİN Doç. Dr. Nuray EMİN
Kastamonu Üniversitesi, Türkiye
Devamını Göster
Özet
In the present study, the efficiency of intra-abdominal use of the macerated oil obtained from Taşköprü Garlic (Kastamonu/Türkiye), which is one of the products with geographical indication-from European Union, in preventing the postoperative adhesions. The chemical structure of the macerated-oil, prepared using fresh-garlic at a concentration of 1.2 g/ml in olive oil, was analyzed by spectrophotometric and chromatographic methods. In in vivo experiments, Wistar Albino rats (n=8) were applied cecal abrasion under general anesthesia. Abrasion zone was treated with physiological saline solution in control group (K) and different doses of macerated oil (0.5-1 ml) in study groups-(S1 S2). Macroscopic-adhesion-scoring-(MAS) between 0-4 was performed for all the subjects on postoperative days 3-28. After staining the tissue-samples, which were taken from subjects found to have adhesion, histopathological adhesion scoring (HAS) was performed between 0 3. On day 3, adhesion was detected in all the subjects. The adhesions reached MAS-2 level in the K and were in MAS 1 level in the subjects in S1 S2. On day 28, no adhesion was observed in S1-S2, whereas adhesions in K remained at the level MAS-2. Moreover, HAS were found to be HAS-1 in S1 S2-K on day 3 whereas it was found to be HAS-2 in K subjects, where adhesion formation continued, on day 28. As a result, the garlic-macerated-oil, obtained by soaking fresh garlic in olive oil for a time, is a low cost and effective agent for adhesion prevention, which will be easily produced and applied by clinicians.
Anahtar Kelimeler
Makale Türü Özgün Makale
Makale Alt Türü Ulusal alan endekslerinde (TR Dizin, ULAKBİM) yayınlanan tam makale
Dergi Adı Türk Doğa ve Fen Dergisi
Dergi ISSN 2149-6366
Dergi Tarandığı Indeksler TR DİZİN
Makale Dili İngilizce
Basım Tarihi 12-2022
Cilt No 11
Sayı 4
Sayfalar 79 / 87
Doi Numarası 10.46810/tdfd.1184982
Makale Linki http://dx.doi.org/10.46810/tdfd.1184982
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
Google Scholar 2
The Use of Macerated Garlic (Allium Sativum L.) Oil in Preventing the Postoperative Adhesions in Rats

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