A Maternal High-Fat Diet Causes Anxiety-Related Behaviors by Altering Neuropeptide Y1 Receptor and Hippocampal Volumes in Rat Offspring: the Potential Effect of N-Acetylcysteine
Yazarlar (3)
Doç. Dr. Kıymet Kübra TÜFEKCİ Kastamonu Üniversitesi, Türkiye
Dr. Öğr. Üyesi Elfide Gizem Bakırhan Adıyaman Üniversitesi, Türkiye
Doç. Dr. Funda TERZİ Kastamonu Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Molecular Neurobiology (Q2) | ||
| Dergi ISSN | 0893-7648 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 03-2023 |
| Cilt / Sayı / Sayfa | 60 / 3 / 1499–1514 | DOI | 10.1007/s12035-022-03158-x |
| Makale Linki | http://dx.doi.org/10.1007/s12035-022-03158-x | ||
| UAK Araştırma Alanları |
Histoloji ve Embriyoloji
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| Özet |
| The children of obese mothers are known to have a high risk of obesity and metabolic disease and are prone to developing cognitive deficits, although the underlying mechanism is not yet fully understood. This study investigated the relationship between neuropeptide Y1 receptor (NPY1R) and anxiety-like behaviors in the hippocampi of male rat offspring exposed to maternal obesity and the potential neuroprotective effects of N-acetylcysteine (NAC). A maternal obesity model was created using a high-fat (60% k/cal) diet. NAC (150 mg/kg) was administered by intragastric gavage for 25 days in both the NAC and obesity + NAC (ObNAC) groups. All male rat offspring were subjected to behavioral testing on postnatal day 28, the end of the experiment. Stereological analysis was performed on hippocampal sections, while NPY1R expression was determined using immunohistochemical methods. Stereological data … |
| Anahtar Kelimeler |
| Anxiety | High-fat diet | Hippocampus | N-acetylcysteine | Stereology |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 11 |
| Scopus | 13 |
| Google Scholar | 15 |