| Yazarlar |
Mohammed Farahna
|
|
Paul F. Seke Etet
|
|
Sayed Y. Osman
|
Doç. Dr. Kıymet Kübra TÜFEKCİ
Türkiye |
|
Naheed Aamir
|
|
Lorella Vecchio
|
|
Işınsu Alkan
Türkiye |
|
Yousef H. Aldebasi
|
|
Azimullah Sheikh
|
|
John C. Chijuka
|
|
Süleyman Kaplan
Ondokuz Mayıs Üniversitesi, Türkiye |
|
A Adem
|
| Özet |
| Ethnopharmacological relevance The development of compounds able to improve metabolic syndrome and mitigate complications caused by inappropriate glycemic control in type 1 diabetes mellitus is challenging. The medicinal plant with established hypoglycemic properties Garcinia kola Heckel might have the potential to mitigate diabetes mellitus metabolic syndrome and complications. Aim of the study We have investigated the neuroprotective properties of a suspension of G. kola seeds in long-term type 1 diabetes mellitus rat model. Materials and methods Wistar rats, made diabetic by single injection of streptozotocin were monitored for 8 months. Then, they were administered with distilled water or G. kola oral aqueous suspension daily for 30 days. Body weight and glycemia were determined before and after treatment. After sacrifice, cerebella were dissected out and processed for stereological quantification of Purkinje cells. Histopathological and immunohistochemical analyses of markers of neuroinflammation and neurodegeneration were performed. Results Purkinje cell counts were significantly increased, and histopathological signs of apoptosis and neuroinflammation decreased, in diabetic animals treated with G. kola compared to diabetic rats given distilled water. Glycemia was also markedly improved and body weight restored to non-diabetic control values, following G. kola treatment. Conclusions These results suggest that G. kola treatment improved the general condition of long-term diabetic rats and protected Purkinje cells partly by improving the systemic glycemia and mitigating neuroinflammation. |
| Anahtar Kelimeler |
| Ataxia | Garcinia kola | Medicinal plant | Neuroprotection | Purkinje cell | Type 1 diabetes mellitus |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | JOURNAL OF ETHNOPHARMACOLOGY |
| Dergi ISSN | 0378-8741 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q1 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2017 |
| Cilt No | 195 |
| Sayı | 1 |
| Sayfalar | 159 / 165 |
| Doi Numarası | 10.1016/j.jep.2016.11.001 |
| Makale Linki | http://dx.doi.org/10.1016/j.jep.2016.11.001 |
| Atıf Sayıları | |
| WoS | 10 |
| SCOPUS | 11 |
| Google Scholar | 19 |
