Effects of prenatal diclofenac sodium exposure on newborn testis: a histomorphometric study
Yazarlar (9)
H. Arslan Hochschule Furtwangen, Almanya
A. Aktaş Istanbul Üniversitesi, Türkiye
E. Elibol Adiyaman Üniversitesi, Türkiye
O. B.B. Esener Istanbul Üniversitesi, Türkiye
A. P. Türkmen Ondokuz Mayis Üniversitesi, Türkiye
Doç. Dr. Kıymet Kübra TÜFEKCİ Ondokuz Mayis Üniversitesi, Türkiye
M. E. Onger Ondokuz Mayis Üniversitesi, Türkiye
B. Z. Altunkaynak Ondokuz Mayis Üniversitesi, Türkiye
S. Kaplan Ondokuz Mayis Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Biotechnic and Histochemistry (Q4) | ||
| Dergi ISSN | 1052-0295 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2016 |
| Cilt / Sayı / Sayfa | 91 / 4 / 277–282 | DOI | 10.3109/10520295.2016.1151551 |
| Makale Linki | http://dx.doi.org/10.3109/10520295.2016.1151551 | ||
| UAK Araştırma Alanları |
Histoloji ve Embriyoloji
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| Özet |
| Diclofenac sodium (DS) is used primarily to treat fever and to alleviate pain and inflammation. We investigated the effects of DS exposure during gestation on the testes of rat pups to investigate the safety of its use during the prenatal period. Pregnant rats were separated into control, saline, low dose, medium dose and high dose groups. DS was given between weeks 15 and 21 of gestation. Total numbers of spermatogonia and Sertoli cells were counted in the testes of 7-day-old male rats using the physical disector method. By the end of the study, the total number of Sertoli cells was decreased significantly in a dose dependent manner in the medium and high dose groups compared to controls. No significant differences were found in the total number of spermatogonia in the control, saline and low dose DS groups. Medium and high dose DS administration reduced the total number of spermatogonia compared to … |
| Anahtar Kelimeler |
| diclofenac sodium | physical disector | rat | Sertoli cells | spermatogonia | stereology | testis |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 14 |
| Scopus | 21 |
| Google Scholar | 20 |