Effects of the melatonin on the kidney of high fat diet fed obese rats: A stereological and histological approach
Yazarlar (5)
Doç. Dr. Kıymet Kübra TÜFEKCİ Ondokuz Mayis Üniversitesi, Türkiye
Arş. Gör. Elif Kayhan Ondokuz Mayis Üniversitesi, Türkiye
B. Zuhal Altunkaynak Ondokuz Mayis Üniversitesi, Türkiye
Gamze Tümentemur Ondokuz Mayis Üniversitesi, Türkiye
Süleyman Kaplan Ondokuz Mayis Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SCOPUS dergilerinde yayınlanan tam makale)
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| Dergi Adı | Ondokuz Mayis Universitesi Tip Dergisi | ||
| Dergi ISSN | 1300-2996 | ||
| Dergi Tarandığı Indeksler | Scopus, Turkiye Citation Index, World Cat, NLM Catalog (PubMed) | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2013 |
| Cilt / Sayı / Sayfa | 30 / 2 / 153–158 | DOI | 10.5835/jecm.omu.30.02.013 |
| Makale Linki | http://dergi.omu.edu.tr/index.php/JECM/article/view/2789 | ||
| UAK Araştırma Alanları |
Histoloji ve Embriyoloji
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| Özet |
| Obesity is associated with multiple conditions that are known to compromise renal function, including hypertension, diabetes, hyperuricemia, and the metabolic syndrome that can independently have a detrimental effect on renal function. The aim of this study was to examine effects of fatty diet induced obesity and melatonin on kidney in female rats by histological and quantative methods. For this aim, 24 rats were randomly divided into 4 groups including Non-obese control (NC group), Obese control (OC group), Nonobese Melatonin (NOM group) and Obese-Melatonin (OM group) groups. In the obese groups, rats, were fed with high fat diet (40% of calories from fat) for 15 weeks. The rats of the non-obese groups were fed with standard, commercial rat diet during the same period. At the end of the 15th week, rats in the melatonin groups started to received daily injections (i.p.) 10 mg/kg melatonin for 6 weeks. At the end of the experiment, a serial sections of kidneys were stained with Hematoxylen-eosin. Glomerular number (Ng) is considered a major determinant of renal function and outcome. Unbiased stereo logical methods have been used to estimate of Ng. Also histopathological analysis was made on the same sections. Stereological examination of the kidneys showed differences in terms of total kidney volume, volume of cortex, medulla and numerical density of glomeruli among the groups. Light microscopic investigation showed a dilatation in blood vessels and Bowman’s space, mononuclear cell infiltration, degeneration in nephrons, including glomerulosclerosis and tubular defects, and an increase in the connective tissue in the kidneys in … |
| Anahtar Kelimeler |
| Glomerulus | Kidney | Melatonin | Obesity | Physical disector | Stereology |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 12 |
| Google Scholar | 13 |