| Yazarlar |
Doç. Dr. Kıymet Kübra TÜFEKCİ
Ondokuz Mayıs Üniversitesi, Türkiye |
Süleyman Kaplan
Ondokuz Mayıs Üniversitesi, Türkiye |
| Özet |
| Diclofenac sodium (DS) is commonly used for the treatment of acute and chronic pain, even for extended periods of time. Over the years, DS has been associated with toxicity in nervous tissue, in addition to its anti-inflammatory properties. Basic neurobiological research has enhanced our understanding of the biological and pathological outcomes of toxicity. Several studies have suggested DS-induced cytotoxicity in the nervous system. Prenatal toxicities of DS are thought to be capable of leading to postnatal defects. This review describes the morphoquantitative, histological and pathological effects of DS on the central and peripheral nervous systems. Knowledge of these effects may assist with the development of a suitable therapeutic approach. In addition, understanding the mechanism of DS-dependent neuronal impairments may contribute to selection of appropriate antioxidant therapy. |
| Anahtar Kelimeler |
| Diclofenac sodium | Melatonin | Neuroinflammation | Oxidative stress | Toxicity |
| Makale Türü | Diğer (Teknik, not, yorum, vaka takdimi, editöre mektup, özet, kitap krıtiği, araştırma notu, bilirkişi raporu ve benzeri) |
| Makale Alt Türü | SCI, SSCI, AHCI, SCI-Exp dergilerinde yayımlanan teknik not, editöre mektup, tartışma, vaka takdimi ve özet türünden makale |
| Dergi Adı | INFLAMMOPHARMACOLOGY |
| Dergi ISSN | 0925-4692 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 02-2018 |
| Cilt No | 26 |
| Sayı | 1 |
| Sayfalar | 15 / 28 |
| Doi Numarası | 10.1007/s10787-017-0434-0 |
| Makale Linki | http://dx.doi.org/10.1007/s10787-017-0434-0 |
| Atıf Sayıları | |
| WoS | 8 |
| SCOPUS | 13 |
| Google Scholar | 12 |
