Effects of melatonin on diclofenac sodium treated rat kidney: a stereological and histopathological study
Yazarlar (9)
Habib Khoshvakhti Ondokuz Mayis Üniversitesi, Türkiye
Doç. Dr. Kıymet Kübra TÜFEKCİ Ondokuz Mayis Üniversitesi, Türkiye
B. Zuhal Altunkaynak Ondokuz Mayis Üniversitesi, Türkiye
Aysin P. Türkmen Ondokuz Mayis Üniversitesi, Türkiye
Ebru Elibol Ondokuz Mayis Üniversitesi, Türkiye
Işinsu Aydin Ondokuz Mayis Üniversitesi, Türkiye
Elfide G. Kivrak Ondokuz Mayis Üniversitesi, Türkiye
M. Emin Önger Ondokuz Mayis Üniversitesi, Türkiye
Süleyman Kaplan Ondokuz Mayis Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Renal Failure (Q2) | ||
| Dergi ISSN | 0886-022X Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 09-2015 |
| Cilt / Sayı / Sayfa | 37 / 8 / 1379–1383 | DOI | 10.3109/0886022X.2015.1073556 |
| Makale Linki | http://dx.doi.org/10.3109/0886022x.2015.1073556 | ||
| UAK Araştırma Alanları |
Histoloji ve Embriyoloji
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| Özet |
| Objective: In this study, we aimed to investigate the effect of diclofenac sodium (DS) and melatonin (MEL) on kidney of the prenatally administered rats. Materials and methods: Pregnant rats were divided into the control, physiological saline, DS, and DS + MEL groups. All injections were given beginning from the 5th day after mating to the 15th day of the pregnancy. Physical dissector and Cavalieri principle were used to estimate the numerical density and total number of glomeruli and the volumetric parameters of kidney, respectively. Results: Our stereological results indicated that DS application during the pregnancy lead to decrease in the mean volume, numerical density, and total number of the glomeruli (p < 0.05). In addition, we determined that usage of the MEL with the DS caused increases in the mean volume, numerical density, and total number of the glomeruli (p < 0.05). So, there was no significant … |
| Anahtar Kelimeler |
| diclofenac sodium | Kidney | melatonin | microscopy | rat | stereology |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 14 |
| Scopus | 14 |
| Google Scholar | 19 |