| Yazarlar |
Arife Ahsen Kaplan
|
Doç. Dr. Kıymet Kübra TÜFEKCİ
Ondokuz Mayıs Üniversitesi, Türkiye |
|
Ömür Gülsüm Deniz
Ondokuz Mayıs Üniversitesi, Türkiye |
|
Gamze Altun
Ondokuz Mayıs Üniversitesi, Türkiye |
| Özet |
| Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most frequently prescribed medications worldwide. Diclofenac sodium (DS), one of these NSAIDs, has a high specificity for arachidonic acid-degrading cyclooxygenase (COX)-2 enzymes. This drug can be used to relieve neuropathic pain. In this review, we examine the relevant researches, including in vivo, animal, and clinical human studies, with the aim of understanding the effect of DS on the peripheral nerves. In injured nerves, COX-2 is potently upregulated around the injury site. When a nerve is damaged, both COX-1 and COX-2 expression is increased in macrophages and Schwann cells. In addition, COX inhibitors can promote axonal outgrowth in cultured neurons. Neuropathic pain occurs after injury and leads to dysfunction of the peripheral nervous system. NSAIDs can modulate the nociceptive and inflammatory pain pathways and control neuropathic pain. DS may accelerate nerve regeneration and its effects on healing, as well as causing deleterious effects in the developing nerves. DS teratogenicity disrupts myelin sheath thickness and axon structure. Understanding the possible benefits and limitations of DS and specific conditions such as prenatal use will be of benefit in clinical practice. |
| Anahtar Kelimeler |
| Cyclooxygenase | Diclofenac sodium | Neuropathic pain | Nonsteroidal anti-inflammatory drugs | Schwann cells |
| Makale Türü | Diğer (Teknik, not, yorum, vaka takdimi, editöre mektup, özet, kitap krıtiği, araştırma notu, bilirkişi raporu ve benzeri) |
| Makale Alt Türü | SCI, SSCI, AHCI, SCI-Exp dergilerinde yayımlanan teknik not, editöre mektup, tartışma, vaka takdimi ve özet türünden makale |
| Dergi Adı | JOURNAL OF CHEMICAL NEUROANATOMY |
| Dergi ISSN | 0891-0618 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2018 |
| Cilt No | 87 |
| Sayı | 1 |
| Sayfalar | 2 / 11 |
| Doi Numarası | 10.1016/j.jchemneu.2017.08.006 |
| Makale Linki | http://dx.doi.org/10.1016/j.jchemneu.2017.08.006 |
| Atıf Sayıları | |
| WoS | 16 |
| SCOPUS | 20 |
| Google Scholar | 25 |
